Following spinal cord injury in rats, FK506 is able to protect local nerve tissue, promote neural regeneration, reduce neuronal apoptosis and accelerate the recovery of spinal cord functions. Nerve growth factor (NGF) is important in the regulation of central and peripheral nerve cell regeneration, growth differentiation and functions. Previous studies have shown that FK506 and NGF exhibit a sy...

Spinal cord injury (SCI) actuate to complex cellular and molecular interactions within the central nervous system in a heave to repair the initial tissue damage. The pathophysiology of acute spinal cord injury (SCI) involves primary and secondary mechanisms. Neuroinflammation is an important secondary injury process in SCI. The local inflammatory microenvironment within the injured spinal cord ...

BACKGROUND The goal of this study was to describe the hospital-based incidence of traumatic spinal cord injury in Tehran, Iran. METHODS We retrospectively reviewed the hospital records of traumatic spinal cord injury patients, admitted between March 2010 and July 2011 in 61/68 hospitals of Tehran. RESULTS Overall, 138 cases of traumatic spinal cord injury were identified. The majority of pa...

STUDY DESIGN The effect of edaravone, a novel free radical scavenger, was assessed functionally and histologically using a rat spinal cord contusion model. OBJECTIVE To investigate the effect of edaravone on neuroprotection after spinal cord injury in rats. SUMMARY OF BACKGROUND DATA The spinal cord injury results in immediate physical damage (primary injury), followed by a prolonged neural...

Improving neurological outcome after spinal cord injury is a major clinical challenge because axons, once severed, do not regenerate but ‘dieback’ from the lesion site. Although microglia, the immunocompetent cells of the brain and spinal cord respond rapidly to spinal cord injury, their role in subsequent injury or repair remains unclear. To assess the role of microglia in spinal cord white ma...

Background: Despite a higher prevalence of traumatic spinal cord injury (TSCI) amongst Canadian Indigenous peoples, there is paucity studies focused on TSCI. We present the first Canada-wide study comparing TSCI and non-Indigenous peoples. Methods: This retrospective analysis prospectively-collected data from Rick Hansen Spinal Cord Injury Registry (RHSCIR) 2004-2019. divided participants into ...

Spinal cord injury often results in permanent functional impairment. Neural stem cells present in the adult spinal cord can be expanded in vitro and improve recovery when transplanted to the injured spinal cord, demonstrating the presence of cells that can promote regeneration but that normally fail to do so efficiently. Using genetic fate mapping, we show that close to all in vitro neural stem...

When neurons within the motor cortex are fatally injured, their axons, many of which project into the spinal cord, undergo wallerian degeneration. Pathological processes occurring downstream of the cortical damage have not been extensively studied. We created a focal forelimb motor cortex injury in rats and found that axons from cell bodies located in the hindlimb motor cortex (spared by the co...

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