Tyrosine kinase inhibitors (TKIs) are the mainstay of current management chronic myeloid leukemia (CML) [1]. With introduction imatinib, many CML patients in phase (CML-CP) we...

Abstract Thromboinflammation is the major cause of morbidity and mortality in COVID-19 patients, post-mortem examination demonstrates presence platelet-rich thrombi microangiopathy lung other visceral organs. Moreover, persistent microclots were detected both acute long COVID plasma samples. However, molecular mechanism SARS-CoV-2-induced thromboinflammation still unclear. We found that spleen ...

Signalling through protein tyrosine kinases (PTKs) is critical in the regulation of important cellular processes and its deregulation is associated with pathophysiological disorders such as cancer. We investigated the function of the PTK spleen tyrosine kinase (Syk) in the regulation of growth factor signalling pathways in human mammary epithelial cells. Our results show that downregulation of ...