INTRODUCTION Hemoglobin spray (Granulox®) comprises purified hemoglobin and is a novel approach for increasing oxygen availability in the wound bed in diabetic foot ulcer patients. Its mode of action is to bind oxygen from the atmosphere and diffuse it into the wound bed to accelerate wound healing in slow-healing wounds. PATIENTS AND METHODS Wound healing outcomes, that is, wound size, pain,...

As part of the Survey of Painters and Repairers of Auto bodies by Yale (SPRAY), the determinants of isocyanate exposure in auto body repair shops were evaluated. Measurements (n = 380) of hexamethylene diisocyanate-based monomer and polyisocyanate and isophorone diisocyanate-based polyisocyanate were collected from 33 auto body shops. The median total reactive isocyanate concentrations expresse...

BACKGROUND To our knowledge, there are no published studies that evaluated the efficacy of azelastine hydrochloride nasal spray in combination with an intranasal corticosteroid, although anecdotal reports of the use of these agents in combination are common. OBJECTIVE To determine if greater efficacy could be achieved with the intranasal antihistamine azelastine and the intranasal corticoster...

The solidification behavior of droplets as well as spray-deposit of Al-4.5 wt% Cu alloy is simulated by modeling based on heat flow analysis. The model incorporates droplet dynamics and their thermal states during atomization process. The resultant spray enthalpy is used to analyze heat flow during solidification of the spray deposit. The effect of process variables like atomization pressure, m...

for a long time, many efforts have been taken on improving gas turbine performance to increase the propulsive force and keep the chamber walls cool. in this regard, implementation of cyclonic and vortex engines have been proposed. according to increasing in the engine efficiency and keeping the chamber walls cool, the bidirectional vortex flow which is exited in the vortex engine, makes researc...

Bombardier beetles (Brachinini) use a rapid series of discrete explosions inside their pygidial gland reaction chambers to produce a hot, pulsed, quinone-based defensive spray. The mechanism of brachinines' spray pulsation was explored using anatomical studies and direct observation of explosions inside living beetles using synchrotron x-ray imaging. Quantification of the dynamics of vapor insi...

The introduction of organic solvents into an inductively coupled plasma (ICP) has been studied. Limiting aspiration rates for various organic solvents were determined for a Hildebrand nebuliser with a mini-Pyrex spray chamber, a cooled Pyrex spray chamber and a large Pyrex spray chamber. Detection limits for metal species were determined. Linear dynamic ranges were found to be at least 3-4 orde...

       The formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. Consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. Microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a ...

although response to intranasal steroid therapy has been reported in pa¬tients with allergic rhinitis, efficacy of some nasal steroids is noteworthy. this study was undertaken to evaluate the efficacy of a two-week course of fluticasone (flixonase) nasal spray vs. beclomethasone (beconase) nasal spray in patients with symptoms of allergic rhinitis referred to our clinic. this study reviewed six...

The structural and physical stability of solid dispersions have not been adequately explored during spray drying manufacturing processes. In this study a wide range of compositions of naproxen/PVP-VA 64 (poly(1-vinylpyrrolidone-co-vinyl acetate)) and miconazole/PVP-VA 64 solid dispersions prepared by different laboratory spray dryers were collected from various selected locations and used to in...