background: cutaneous malignancies are common in dermatologic practice. due to their relation to sun exposure the characteristics of these malignancies can differ in various geographic locations. this study intends to determine the characteristics of surgically treated cutaneous malignancies and various surgical modalities that have been applied. methods: this was a retrospective study of patie...

Changes in Salivary Antioxidants Patients with Oral Squamous Cell Carcinoma: Systematic Review Study and Meta-Analysis

Background: Carcinomas of esophagus, mostly squamous cell carcinomas, occur throughout the world. There are a number of suspected genetic or environmental etiologies. Human papilloma virus (HPV) is said to be a major etiology in areas with high incidence of esophageal carcinoma, while it is hardly detectable in low incidence regions. This study was designed to evaluate the prevalence of HPV in ...

objective(s): similar characteristics of molecular pathways between cellular reprogramming events and tumorigenesis have been accentuated in recent years. reprogramming-related transcription factors, also known as yamanaka factors (oct4, sox2, klf4, and c-myc), are also well-known oncogenes promoting cancer initiation, progression, and cellular transformation into cancer stem cells. long non-co...

purpose : to develop a guideline for the treatment of incompletely removed histopathologically documented ocular surface neoplasia (ossn) with mitomycin c (mmc). materials & methods : through an interventional case series, 17 eyes of 17 patients presented with incompletely removed ossn were treated according to a protocol using 2-3 alternate 7-day courses of mmc 0.04%. clinical recurrence was r...

background and objective: p53 is a suppressive gene that plays a key role in dna repair and apoptosis. the purpose of this study was to investigate the effect of p53 protein over-expression and some clinicopathological factors on the esophageal squamous cell carcinoma (scc) response to neoadjuvant chemoradiotherapy. patients and methods: in this retrospective cohort study, 44 patients with loca...

introdouction: squamous cell carcinoma is the most common oral cancer and the prognosis because of a late diagnosis remains poor despite numerous treatments. therefore, we conducted a cross-sectional study to investigate the relationships between survival rate(sr) of oral squamous cell carcinoma (oscc) and clinical,demographic, pathological, and molecular factors in yazd city during 1998– 2008....

conclusions despite the fact that abnormalities in p53 and p27kip1 may be involved in the development of oscc, their clinical significance in the studied population seems limited. further investigation on the combined p53/p27kip1 expression may be helpful in predicting the biologic behavior of this tumor. results p53 and p27kip1 expression were found in 28.57% (8 positive versus 20 negative) an...