introduction and aims: the role of human papillomavirus (hpv) in the etiology of esophageal squamous cell carcinoma (escc) is not clear. previous studies have found highly variable (from 0% to 67%) prevalence of hpv in escc tumor. however, prevalence of hpv in escc tumor seems to be higher in areas with high incidence of escc , such as china and south africa. iran is one of the areas of the wor...

objective(s):  cd44 is a member of the cell adhesion molecules family. naturally, cd44s, along with cd44v3 influence the cell motility, migration, and adhesion, while in tumor cells they lead to tumor invasion, progression, and metastasis. the purpose of this research is to evaluate the cd44s and cd44v3 expression in esophageal squamous cell carcinoma (escc) and to reveal their correlations wit...

introduction: her2/neu, a member of the epidermal growth factor receptor family, has been shown to be over-expressed in some tumors. the purpose of this study was to determine the salivary levels and tissue expression of her2/neu in patients with head and neck squamous cell carcinoma (hnscc) and their correlation with clinicopathologic parameters.   materials and methods: enzyme-linked immunoso...

Reconstructing a large cutaneous cheek defect post tumour excision poses great challenge to the reconstructive surgeon. The surgical options are limited for functional and aesthetically acceptable outcome. microvascular free flap which is currently gold standard still not common place in our practice Nigeria. Cervicofacial flap, single stage procedure, offers an excellent alternative as it can ...

Role of the protein overexpression is very important in the pathogenesis, diagnosis and prognosis of neoplasia. Cases of overexpression of p53 and Ki67 proteins were investigated in 19 ocular squamous cell carcinomas (OSCC) in dairy cows. Microscopically, insix cases the tumors were carcinoma in situ (noninvasive carcinoma, G0), and in the remaining 13 cases the tumors were invasive carcinoma. ...

Background: Although systemic immune-inflammation index (SII) correlates with patient survival in various solid malignancies limited information is available the setting of oral cavity squamous cell carcinoma (OCSCC).

  Amoebiasis of the uterine cervix is an extremely rare entity and presentation as carcinoma cervix has only been reported once in the extensively searched English literature. It can clinically simulate cervical malignancy by virtue of surface papillomatous and overall ulcerated and necrotic appearance. We present a case of amoebic cervicitis in a 55-year old female which was suspected to be a...

background : angiogenesis is essential for the growth, invasion and metastasis of solid tumors. research on related factors such as microvessel density can be helpful in predicting a tumor's behavior. cd105 has been introduced as a marker of angiogenesis which stains vessels that are in the proliferating stage. there are some controversies about the relation of microvessel density and clinicopa...

Pilonidal disease consists of a hair-containing sinus or abscess occurring most frequently in intergluteal cleft. This disease is generally benign. Although very uncommon entity, it seems reasonable to be aware of possible malignancy in longstanding cases. We report a case of squamous cell carcinoma in a 52- year-old man, with a prolonged history of pilonidal disease and ulceration since 3 mont...