B cells utilize three DNA alteration strategies-V(D)J recombination, somatic hypermutation (SHM) and class switch recombination (CSR)-to somatically mutate their genome, thereby expressing a plethora of antibodies tailor-made against the innumerable antigens they encounter while in circulation. Of these three events, the single-strand DNA cytidine deaminase, Activation Induced cytidine Deaminas...

ABSTRACT Dynamical friction is often modelled with reasonable accuracy by the widely used Chandrasekhar formula. However, in some circumstances, Chandrasekhar’s local and uniform approximations can break down severely. An astrophysically important example ‘core stalling’ phenomenon seen N-body simulations of massive perturber inspiralling into near-harmonic potential a stellar system’s constant...

In two recent papers, Arenz et al. (2014a) and Bischoff et al. (2014) provide structural insights into drug-induced, peptide-mediated stalling of the ribosome.