OBJECTIVE To compare adherence with statin therapy in patients switching to single-pill amlodipine besylate/atorvastatin calcium with patients adding a separate statin to their amlodipine regimen. METHODS We identified hypertensive patients prescribed amlodipine who switched to amlodipine/atorvastatin (switch) or added a statin to their amlodipine regimen (add-on) from July 2004 to June 2007....

PURPOSE OF REVIEW Despite advances in medical therapy and percutaneous revascularization, patients with acute coronary syndrome face a high risk of early, recurrent cardiovascular events. Interventions targeting atherogenic lipoproteins may favorably modify this risk. RECENT FINDINGS Two randomized clinical trials, MIRACL and PROVE-IT, demonstrated efficacy of early, intensive statin therapy ...

BACKGROUND statin drugs may induce skeletal myopathy, but might also have the potential to improve rehabilitation outcomes by improving sarcopenia or by preventing intercurrent illness. We examined the association between statin use and functional outcomes in the rehabilitation of older people. METHODS retrospective cohort study using routinely collected clinical data. Admissions to Royal Vic...

Background Statin utilization had been associated with improved survival after cardiac surgery. We aim to study whether perioperative treatment with statin could be associated with increased postoperative complications. Design This was a retrospective, descriptive, single-center study. Settings We analyzed morbidity after cardiac surgery as well as the outcome related to statin therapy in a...

INTRODUCTION Statins are reported to have anti-inflammatory and anti-oxidative effects aside from cholesterol-lowering effects. This study aimed to evaluate the effects of statin therapy on oxidized LDL (Ox-LDL) and the clinical outcome of patients with acute ischemic stroke (AIS). METHODS This prospective study enrolled 120 patients with AIS divided in the statin (n = 55) and non-statin (n =...

BACKGROUND Hypothesizing that statins may be useful as adjuvant treatment for renal anemia, we examined the association between statin prescription (Rx) and erythropoiesis-stimulating agent (ESA) hyporesponsiveness in Japanese hemodialysis (HD) patients prescribed ESAs. METHODS We examined 3,602 patients in 60 HD facilities dialyzed 3 times/week for ≥4 months from the Japan Dialysis Outcomes ...

OBJECTIVE Recent studies have demonstrated that statins have pleiotropic effects, including anti-inflammatory effects and atrial fibrillation (AF) preventive effects. The objective of this study was to assess the efficacy of preoperative statin therapy in preventing AF after coronary artery bypass grafting (CABG). METHODS 221 patients underwent CABG in our hospital from 2004 to 2007. 14 patie...

Background and aimsCardiovascular disease is the main cause of death in end-stage kidney (ESKD) patients. We aimed to explore association between statin initiation after starting dialysis all-cause mortality statin-naïve ESKD patients.MethodsWe analyzed nationwide claims data incident patients from 2010 2017 South Korea. Patients who had previous cardiovascular events or were administered stati...

BACKGROUND Prior studies have found that patients taking single-pill amlodipine/atorvastatin (SPAA) have greater likelihood of adherence at 6 months than those taking 2-pill calcium-channel blocker and statin combinations (CCB/statin). This study examines whether this adherence benefit results in fewer cardiovascular (CV) events. METHODS A retrospective cohort study was conducted using admini...

BACKGROUND Evidence of the associations between statin adherence level, health care costs, and utilization is still limited. It is not clear whether better clinical outcomes derived from increasing statin adherence levels can be translated into cost savings and lower health care utilization. OBJECTIVES To evaluate the associations between statin adherence level, health care costs, hospital ad...