parkinson’s disease (pd) is the second most common neurodegenerative brain disorder which is around 1.5 times more common in men than in women. currently, drug medications, surgery, and lifestyle changes are common approaches to pd, while all of them focused on reducing the symptoms. therefore, regenerative medicine based on stem cell (sc) therapies has raised a promising hope. various types of...

background differences in causes, severities, areas of stenosis, and the association with swallowing and phonation of larynx and trachea can result into laryngotracheal stenosis (lts).this study evaluated the healing effect of bone marrow stem cells (bmscs) in experimentally induced lts dog model. methods seven dogs were enrolled. bmscs were isolated from proximal humerus and shoulder of a dog ...

background: stem-cell therapy plays a preventive role for different complications of diabetes, including diabetes nephropathy. the current phase 3 single-arm clinical trial is designed to investigate the potential protective effect of allotransplantation of fetal liver-derived cell suspension in diabetic nephropathy. methods: seventy-four diabetic patients with type 1 were selected according to...

introduction: accumulating evidences indicated that during increasing of the animals' age, the number and the functional properties of hematopoietic stem cells (hscs) become altered because of a gradual decrease in replication potential.  the efficient factors in this process are dna damaging, reduced telomerase activity, shortening of telomeres and oxidative stresses. for overcoming these fact...

introductio: hematopoietic stem cell transplants (hsct) are considered as treatment options for patients with solid tumors. transplant numbers have changed significantly over the last decade. we have done autologous and allogeneic hsct for treatment of solid tumor patients in our center. methods: in order to show the transplant effect on solid tumor treatment, we collected data from 71 patients...

introduction: bronchiolitis obliterans (bo) is one of the most important pulmonary complications of hematopoietic stem cell transplantation (hsct). we decided to evaluate the prevalence and risk factors of bo in hsct patients in the shariati hospital oncology research center. materials and methods: forty two patients, who had had hsct for at least 6 months ago, completed the study. the diagnosi...

abstract background: sodium arsenite (sa) recently has been recommended to be used in malignancy therapy. our studies showed, sa in short and long period of treatment caused reduction of rats bone marrow mesenchymal stem cells (mscs) viability and induced caspase dependent apoptosis. the aim of this study was to investigate the effect of sa on osteogenic differentiation of mscs. methods: mscs w...

introduction: type i diabetes mellitus is caused by autoimmune destruction of the insulin-producing β-cells. a new potential method for curing the disease is transplantation of differentiated insulin- secreting cells from human embryonic stem cells. methods: human embryonic stem cell lines (royan h1) were used to produce embryoid bodies. differentiation carried out by growth factor-mediated sel...

purpose: to report the clinical findings and compare the outcomes of different surgical techniques evolved over time in a large series of patients with delayed-onset mustard gas keratitis (mgk). methods: this interventional retrospective case series includes patients with complications of delayed mgk. medical and surgical interventions to address dry eye, limbal ischemia and limbal stem cell de...

a neurological disorder is any disorder of the nervous system is usually due to cell loss. the ultimate goal of cns therapy is to replace lost cells and tissue. there is no neuroprotective, pharmacological and effective treatment available that restores the injury-induced loss of function. recent studies suggest that identification of adult neural stem/progenitor cells indwelling in the neuroge...