Background Prostaglandin El is a potent vasodilator with anti-inflammatory and antiplatelet effects. We tested the hypothesis that prostaglandin El attenuates or prevents platelet aggregation-associated cyclic flow variations (CFVs) in severely stenosed and endothelium-injured coronary arteries. Methods and Results We induced CFVs in 21 dogs by placing an external constrictor around the left an...

In the present study a mathematical model for the blood flow in stenosed artery in the presence of magnetic field is proposed. The laminar, incompressible, fully developed, non-Newtonian flow of blood in an artery having multiple stenosis is numerically studied under the action of transverse magnetic field. The governing equations are transformed by using a radial transformation and the numeric...

Background: Coronary heart disease is a rising cause of adult death in Nepal. Diagnostic and interventional facilities such as coronary angiography and angioplasty have also collaterally improved in Nepal over the last decade. This study explores the most common coronary vessels involved in the Nepalese population based on the coronary angiographic findings. Methods: This is a retrospective stu...

Two patients with previous brain stem infarction and current symptoms of vascular insufficiency in the basilar circulation had evidence of vertebral artery occlusive disease. Angiography demonstrated ostial stenosis of the dominant right vertebral artery and retrograde flow down the left vertebral artery to the level of the transverse process of C2 in the first case and to the level of a severe...

Methods: A 73-year-old female presented with rapidly deteriorating renal function and uncontrolled hypertension secondary to ischemic nephropathy due to chronic renovascular occlusive disease. The patient had failed prior Percutaneous Transluminal Angioplasty (PTA) attempts. Preoperative evaluation showed the right kidney to be atrophied and normal size left kidney. Intraoperative exploration r...