BACKGROUND In autosomal dominant polycystic kidney disease (ADPKD), total kidney volume (TKV) is regarded as an important biomarker of disease progression and different methods are available to assess kidney volume. The purpose of this study was to identify the most efficient kidney volume computation method to be used in clinical studies evaluating the effectiveness of treatments on ADPKD prog...

BACKGROUND Digital image analysis (DIA) enables better reproducibility of immunohistochemistry (IHC) studies. Nevertheless, accuracy of the DIA methods needs to be ensured, demanding production of reference data sets. We have reported on methodology to calibrate DIA for Ki67 IHC in breast cancer tissue based on reference data obtained by stereology grid count. To produce the reference data more...

Any investigation of the total number of neurons in a given brain region must first address the following questions. What is the best method for estimating the total number of neurons? What are the validity and the expected precision of the obtained data? What precision must the estimates attain with respect to the scientific question? In the present study, these questions were addressed using ...

there are extensive evidences that show axonal processes of the nervous system (peripheral and/or central) may be degenerated after nerve injuries. wallerian degeneration and chromatolysis are the most conspicuous phenomena that occur in response to injuries. in this research, the effects of post-operative time following sciatic nerve crush on the number of spinal motoneurons were investigated....

background: phthalate esters have been shown to cause reproductive toxicity in both developing and adult animals. objective: this study was designed to assess long-term effects of maternal exposure to di (2-ethylhexyl) phthalate (dehp) on reproductive ability of both neonatal and adult male offspring. materials and methods: 60 female rats randomly divided in four equal groups; vehicle control a...