Inbred BALB/c and C57BL/6 mice as well as their F1 hybrids were reared in either an inbred or hybrid maternal environment prenatally and/or postnatally, and were later tested for several behaviours prior to histological study of the brain at 100 days after birth. Whereas measures of spatial memory showed hybrid vigour or overdominance, measures of hippocampal mossy fibres showed intermediate in...

MATING behavior in animals is complex and determined by diverse genetic and environmental factors. As one aspect of this behavior, mating frequency in chickens has received considerable attention ( UPP 1928; WOOD-GUSH 1956; MCDANIEL and CRAIG 1959; SIEGEL 1959; CARBAUGH, SCHEIN and HALE 1962; JUSTICE, MCDANIEL and CRAIG 1962). These reports, while not in agreement on the best procedures for the...

Records of five inbred lines at the Livestock and Range Research Laboratory were used to evaluate effects of inbreeding and heterozygosity on preweaning traits. Members of each line were descendants of a single founder Hereford bull. A total of 8,065 records of birth weight and 7,380 records of preweaning daily gain and weaning weight were analyzed by derivative-free REML using a model that inc...

Cytosine DNA methylation is one avenue for passing information through cell divisions. Here, we present epigenomic analyses of soybean recombinant inbred lines (RILs) and their parents. Identification of differentially methylated regions (DMRs) revealed that DMRs mostly cosegregated with the genotype from which they were derived, but examples of the uncoupling of genotype and epigenotype were i...

Coronary artery anatomic patterns were determined in 4,500 rats obtained from three unrelated inbred strains. Four basic patterns were defined based on the presence of one or two primary trunks arising from separate ostia on each side. The frequency distribution of these patterns was significantly different among the three strains. Breeding experiments showed that the patterns are polygenetical...

The recent advent of molecular markers has created a great potential for the understanding of quantitative inheritance. In parallel to rapid developments and improvements in molecular marker technologies, biometrical models have been constructed, refined and generalized for the mapping of quantitative trait loci (QTL). However, current models present restrictions in terms of breeding designs to...

HE role of genetics in determining arterial blood pressure has been the s u b of numerous papers in the medical literature. Familial aggregation of blood pressure levels is well documented in human populations (summarized by MCKUSICK 1960; SCHTNEITZER et al. 1962; ROBERTS 1964). Although there is little doubt that genetic factors to some degree determine systolic blood pressure levels. there is...

Many mice of the inbred strain BALB/cCF have deficient corpus callosum, and a few of them have total absence of this large forebrain commissure. Reciprocal F1 hybrid crosses with the inbred strains A/J, C57BL/6J, and DBA/2J revealed that inheritance of the defect is completely recessive. Reciprocal backcrosses to BALB/cCf revealed that inheritance is not attributable to a single Mendelian locus...

The result of crossing two well-inbred lines of organisms for each of which there has been established by repeated test a characteristic relationship between some aspect of performance or behavior and a measured external condition governing the performance, is important in at least two respects. I t should contribute to the demonstration of the degree of reality inhering in the formulation used...

HE manifestation of a quantitative trait is dependent upon the relationship Tof a number of genes in the same and different chromosome pairs. The nature of these relationships can be studied by comparing the effects of homologous chromosomes from different strains in a controlled genetic background. In experiments of this kind, the effects of the genes involved can be described in terms of effe...