In order to optimize high-speed systems, designers need tools that automatically generate reduced-order SPICE compatible models from geometric descriptions of interconnect and packaging. In this paper, we consider structures small compared to a wavelength, and use a discretized integral formulation combined with an Arnoldi-based model-order reduction strategy to compute efficiently accurate red...

Vital decisions made at the strategic level in an organization are not only intricate but also costly to alter. It is therefore important to find a comprehensive approach to deal with such a possibility. One of the major problems of a common balanced scorecard (BSC)-based model in strategic management is lack of a ranking system for strategic objectives in order to enable prioritization of the ...

one of the most important problems in the system reliability optimization is redundancy allocation problem that has been studied in different system configurations. k-out-of-n structure is a general system configuration and offers enhanced capabilities for analyzing more design problems. hence, in this paper, the redundancy allocation problem of k-out-of-n systems is studied. in the most previo...

A self-adaptation of arbitrary normal mutation distributions within the concept of muta-tive strategy parameter control (MSC) using a newly formulated mutation operator is introduced. The coordinate system independent formulation ensures the invariance of the algorithm towards arbitrary linear transformations , which is a novelty for self-adaptation within the concept of MSC. To enable a sensib...

Over a number of years quite a large body of literature on planning for information systems has been built up. Case-studies have been carried out, success factors have been investigated, and methods for information strategy planning have been examined. However, one does not find a sound conceptual foundation . of the planning for information systems in literature. Based on the strategy models o...

Paclitaxel is an anticancer agent effective for the treatment of breast, ovarian, lung, and head and neck cancer. Because of water insolubility, paclitaxel is formulated with the micelle-forming vehicle Cremophor EL to enhance drug solubility. However, the addition of Cremophor EL results in hypersensitivity reactions, neurotoxicity, and altered pharmacokinetics of paclitaxel. To circumvent the...

This paper presents an optimum design methodology for obtaining the highest robust performance using fuzzy multi-objective formulation strategy. The target performance and its variation, as functions of normally distributed variables with stochastic independence, are simultaneously minimized in this design process. A functional representation of the variability of the performance and the comput...

Therapeutic drug monitoring of cyclosporine A in renal transplant patients is normally performed by measuring pre-dose trough levels or doing area under the curve profiles from all possible sampling points. On the basis of good correlation between predicted area under the curve from limited sampling points and actual area under the curve (literature survey), a limited sampling strategy at 1, 3 ...