The chemical properties of these two substances are strikingly similar. Both compounds are irreversibly decomposed under biological conditions. Alloxan has a half life of 1 minute (1) and dehydroascorbic acid has a half life of a few minutes (2). Alloxan is readily reduced to dialuric acid (3) with which it forms alloxantin (3). Dehydroascorbic acid is readily reduced to ascorbic acid (4) and a...

L-Isoleucine was discovered in 1904 by Ehrlich (l), and its constitution established 3 years later (a) by degradation to d-isoamylamine and (b) by synthesis through the Strecker reaction with d-isovaleraldehyde (2). The synthetic product, however, appeared on fractional crystallization to be optically inhomogeneous, and Ehrlich attributed this to the presence in nearly equal parts of natural is...

The phosphoroclastic decomposition of pyruvic acid to acetic and formic acids by enzyme extracts of Escherichia coli has been an object of study ever since acetyl phosphate was tentatively identified as an intermediate of this reaction (1). The finding by Utter, Lipmann, and Werkman that isotopic carbon of formate was incorporated into the carboxyl group and that the carboxyl carbon of acetate ...

Combined thermodynamic/kinetic events amount to a kinetically controlled Dynamic Combinatorial Resolution (DCR) process, where the lability of the molecules/aggregates are used to generate dynamics, and the species experiencing the lowest activation energy is selected via kinetic process. Both interand intramolecular processes can be performed using this concept, resulting in complete resolutio...