A Strecker-type synthesis of glycine by reacting NH(3), H(2)C=O and HCN in presence of ice water (H(2)O-ice) as a catalyst has been theoretically studied at B3LYP/6-31+G(d,p) level within a cluster approach in order to mimic reactions occurring in the interstellar and circumstellar medium (ICM). Results indicate that, despite the exoergonic character of the considered reactions occurring at the...

A rapid and versatile one-pot, 2 x 10 min microwave protocol for the preparation of N-1 and C-6 decorated 3,5-dichloro-2(1H)-pyrazinones was developed. Comparable reaction sequences using classical conditions require about 1-2 days of heating. The alpha-aminonitrile was first generated in a Strecker reaction and thereafter cyclized under microwave heating. The microwave approach developed offer...

New N-substituted ?-aminonitrile derivatives from menthol were synthesized by consecutive succinic ester formation, propargylation, 1,3-dipolar Huisgen cycloaddition and Strecker reaction. The structures of the compounds confirmed diverse spectroscopic techniques including 1HNMR, 13C-NMR, ESI-MS IR. novel evaluated for their in vitro antibacterial activities against Staphylococcus aureus as Gra...

The development of synthetic methods that afford high yields of the target products with a minimal environmental footprint is a major goal in organic synthesis. The use of carbocatalysts is attractive owing to their low cost and high natural abundance. Carbocatalyts have been applied in the oxidative aromatization and preparation of heteroaromatic compounds such as pyridine, imidazole, and pyri...

Uncommon reversible guest-induced metal-hemilabile linker bond dynamics in MOF MFM-300(Sc) was unraveled to switch on/switch off catalytic open metal sites. The activity of this with non-permanent sites demonstrated using a model Strecker hydrocyanation reaction as proof-of-concept. Conclusively, the evidenced be fully reversible, preserving conversion performance and structure integrity over m...