Involvement of endogenous nitric oxide in the effects of kyotorphin and its synthetic analogue on immobilization and cold stress-induced analgesia E. B. Dzambazova*, A. I. Bocheva, V. P. Nikolova 1 Department of Pathophysiology, Faculty of Medicine, Medical University, 2 Zdrave Str., 1431 Sofia, Bulgaria 2 Department of Biology, Faculty of Medicine, Medical University, 2 Zdrave Str., 1431 Sofia...

Aims & Objectives: The present study consists in evaluation of the effects of the dipeptides Kyotorphin (Kyo) and D-Kyotorphin (D-Kyo) on nociception and plasma levels of adrenocorticotrophic hormone and corticosterone after 1 hour of heat stress in rats. Materials & Methods: Kyo and D-Kyo`s effects on nociception were evaluated by Paw pressure and Hot plate test after 1 hour of heat stress. Pl...

beta-Carboline-3-carboxylic acid ethyl ester (beta-CCE) dose-dependently potentiated psychological-stress induced analgesia (PSY-SIA), and the effect was reversed by diazepam. Concurrent exposure to PSY stress or concomitant treatment with beta-CCE blocked the development of analgesic tolerance to morphine; the effect of PSY stress was antagonized by diazepam, and that of beta-CCE was reversed ...

Stress and chronic pain have been shown to prevent the development of tolerance to morphine analgesia, which appears to be related to neuroendocrine activity and alternation in neurochemicals. Also the involvement of nitric oxide (NO) has been implicated in tolerance to morphine analgesia. In our pervious study, we showed that co-administration of swim stress (ss) with chronic morphine, prevent...

The aim of the No Pain in Labour (NoPiL) study was to evaluate the stress and clinical outcome of infants vaginally born without maternal analgesia and after maternal epidural or systemic analgesia. We studied 120 healthy term infants, 41 in the no analgesia group, 38 in the epidural analgesia group, and 41 in the systemic analgesia group. Cortisol, beta-endorphin, oxidative stress markers (ie:...

background: usual dosage  of morphine  (10 mg/kg) induces  analgesia  and ultra-low dose (uld) of morphine (1 μg/kg); hyperalgesia, and  c-fibers are also bearing  μ- opioid receptors; here the importance  of c-fibers on pain and  morphine   induced  analgesia/hyperalgesia  is questioned   and  investigated    using   pain   evaluation methods and infant capsaicin treating  for c-fibers lesioni...

Cancer pain directly affects the patient's quality of life. We have previously demonstrated that the subcutaneous administration of the mammary adenocarcinoma known as Ehrlich tumor induces pain in mice. Several studies have shown that the flavonoid quercetin presents important biological effects, including anti-inflammatory, antioxidant, analgesic, and antitumor activity. Therefore, the analge...

  In this study, the effects of lead acetate on two types of pain (nociception and inflammation) induced by formalin and its interaction with the opioid system and morphine-induced analgesia were examined. Male albino mice weighing 22-27 g were used in the experiments. Morphine was administered subcutaneously 30 minutes before formalin injection. Lead acetate was intraperitoneally administered ...