Purpose – To show how Bateson’s difference which makes a difference can be interpreted from a cybernetic view, i.e. in terms of control theory. Design/methodology/approach – Depending on the observer’s choice of the system boundaries, communication or structural coupling may be recognized. With the help of Bateson’s example he uses to explain his term of information the paper demonstrates how t...

This study investigated the performance and aeroelastic characteristics of a wind turbine blade based on strongly coupled approach (two-way fluid structure interaction) to simulate the transient FSI[1] responses of HAWT[2]. Aerodynamic response was obtained by 3D CFD-URANS approach and structural response was obtained by 3D Finite element method. ...

G protein-coupled receptors (GPCRs) are membrane receptors; approximately 40% of drugs on the market target GPCRs. A precise understanding of the activation mechanism of GPCRs would facilitate the development of more effective and less toxic drugs. Heterotrimeric G proteins are important molecular switches in GPCR-mediated signal transduction. An agonist-activated receptor interacts with specif...

Globular proteins often contain structurally well-resolved internal water molecules. Previously, we reported results from a molecular dynamics study that suggested that buried water (Wat3) may play a role in modulating the structure of the FK506 binding protein-12 (FKBP12) (Park and Saven, Proteins 2005; 60:450-463). In particular, simulations suggested that disrupting a hydrogen bond to Wat3 b...

The evolution of the Web and its applications has undergone in the last few years a mutation towards technologies that include the social dimension as a first class entity in which the users, their interactions and the emerging social networks are the center of this evolution. The web is growing and evolving the intelligibility of its resources and data, the connectivity of its parts and its au...

We work on the design of computerized systems that support experts during their complex and poorly formalized data interpretation process. We consider interpretation as the process by which high level abstracted information is attached to data. We assume that a computer could efficiently helps an expert in such a process via a structural coupling (Maturana and Varela, 1994) based on their inter...

Organisms are embedded in environments, with which they engage in an ongoing two-way interaction called structural coupling. It is in this context that an organism develops, behaves, thrives, and ultimately dies. This paper introduces a network-based methodology for analyzing how an organism and environment unfold together through structural coupling, and demonstrates this methodology in a cell...

Abstract A robust three-dimensional multiscale structural optimization framework with concurrent coupling between scales is presented. Concurrent ensures that only the microscale data required to evaluate macroscale model during each iteration of collected and results in considerable computational savings. This represents principal novelty this permits a previously intractable number design var...