IBMPFD/ALS is a genetic disorder caused by single amino acid mutation on the p97 ATPase, promoting ATPase activity and cofactor dysregulation. The disease mechanism underlying malfunction remains unclear. To understand how alters regulation, we assembled full-length p97R155H with its p47 first visualized their structures using single-particle cryo-EM. More than one-third of population was dodec...

: One of the tools for the architectural advent form is the structure, while architecture and structures, particularly in our sociable Iran, are separated from each other. Most successful buildings have dominating designers who are proficient in structural issues and have a comprehension of the structural system's behavior. The extent of attention to the structure of the building will inevitabl...