Objective(s): Recently, we showed that some new synthetic compounds structurally related to cilostamide (4-(1,2-dihydro-2-oxoquinolin-6-hydroxy)- N-cyclohexyl-N-methylbutanamide), a selective phosphodiesterase 3 (PDE3) inhibitor, produce inotropic effect comparable to that of IBMX (3-isobutyl-1-methylxanthine), a non-selective PDE inhibitor, but with differential chronotropic effect. In this in...

Detailed atomistic computer simulations are now widely used to study biological membranes, including increasingly mixed lipid systems that involve, for example, cholesterol, which is a key membrane lipid. Typically, simulations of these systems start from a preassembled bilayer because the timescale on which self-assembly occurs in mixed lipid systems is beyond the practical abilities of fully ...

We present a detailed study of the electronic and magnetic interactions Ba2CoO4, structurally very uncommon because isolated CoO4 distorted tetrahedral coordination. show presence Co(d)-O(p) hybridized states characterized by spin polarized oxygen atoms, with their moments parallel to that on Co. The calculated isotropic exchange interaction parameters, which include contributions from ligand s...

Leydig cells are the primary site of androgen biosynthesis in males. Several environmental toxicants target steroidogenesis resulting in both developmental and reproductive effects including testicular dysgenesis syndrome. The aim of this study was to evaluate the effect of several structurally diverse endocrine disrupting compounds (EDCs) on steroidogenesis in a novel BLTK1 murine Leydig cell ...

Iron transport into the cells of microbes is mediated by low— molecular—weight sequestering agents (siderophores) which are powerful and highly specific sequestering agents for Fe(III). The current status of iron uptake by E. coli as mediated by the tricatechol siderophore entero— bactin will be reviewed. Recently the synthesis of kinetically inert Rh(III) complexes of enterobactin analogs have...

The Universal Extra Dimensions model has been implemented in the PYTHIA generator from version 6.4.18 onwards, in its minimal formulation with one TeV sized extra dimension. The additional possibility of gravity-mediated decays, through a variable number of eV sized extra dimensions into which only gravity extends, is also available. The implementation covers the lowest lying Kaluza-Klein (KK) ...

Background: The Get4/Get5 protein complex is a homodimer mediated by the Get5 carboxyl domain. Results: The Get5 homodimerization motif forms a structurally conserved helical domain allowing Get4/Get5 to adopt an extended solution conformation. Conclusion: Get5 homodimerization is mediated by a 35-residue sequence stabilized by a few conserved hydrophobic interactions. Significance: The Get5 ca...