This study investigated the effect of morin on membrane bound enzymes and glycoproteins in normal and streptozotocin (STZ)-induced diabetic Wistar rats. Diabetes was induced in rats by an intraperitoneal injection of STZ, dissolved in citrate buffer (0.01 M, pH 4.5) and injected to overnight fasted rats with a dose of STZ 50 mg/kg. Morin was dissolved in carboxy methyl cellulose (CMC) at a dose...

Background: Hypertension is considered an independent risk factor for cardiovascular mortality in diabetic patients. The present study was designed to determine the role of gamma amino butyric acid B (GABAB) receptor and L-arginine (L-Arg) in GABA-induced vasorelaxation in normal and streptozotocin-induced diabetic rat vessels. Methods: Diabetes was induced by a single i.p. injection of strepto...

BACKGROUND To study the effects of an aqueous extract of date fruit (Phoenix dactylifera L. Arecaceae) diet on diabetic polyneuropathy (DPN) in streptozotocin- (STZ-) induced diabetic rats. METHODS The effects of a date fruit extract (DFE) diet on diabetic neuropathy in STZ-induced diabetic rats were evaluated and compared with a nondiabetic control group, diabetic control group (sham), and v...

objective: the present study was hypothesized to investigate the beneficial effects of fresh, aged, and cooked garlic extracts on blood glucose and memory of diabetic rats induced by streptozocine (stz). material and methods: diabetes was induced by an intraperitoneal injection of stz (60 mg/kg body weight). an oral dose of 1000 mg/kg of each garlic extract was given daily for 4 weeks after dia...

Angiotensin II AT2 receptors have been implicated to play a role in the regulation of renal/cardiovascular functions under pathological conditions. The present study is designed to investigate the function of the AT2 receptors on renal sodium excretion and AT(2) receptor expression in the cortical membranes of streptozotocin (STZ)-induced diabetic rats. The STZ treatment led to a significant we...

Background and Aim: Diabetes can lead to reduced fertility in men by production of free radicals. Crocin (the effective component of saffron) with its antioxidant property can be effective in elimination of free radicals. We evaluated the effects of crocin on the reproductive parameters of the STZ –induced diabetic male Wistar rats. Materials and Method: Rats were made diabetic with...

background: the relationship between the high activity of aldose reductase (ar) and diabetic cataract formation has been previously investigated. the purpose of the present study was to determine the preventing effect of melatonin on streptozotocin (stz)-induced diabetic cataract in rats. methods: 34 adult healthy male sprague-dawely rats were divided into four groups. diabetic control and diab...

We investigated the protective and antioxidative effects of selenium nanoparticles (SeNPs) in streptozotocin STZ-induced diabetic rats. STZ-diabetic rats were exposed daily to treatments with SeNPs and/or insulin and then the effect of these treatments on the parameters correlated to oxidative damage of the rat testes were assessed. Biochemical analysis revealed that SeNPs are able to ameliorat...

The aim of the present study was to explore the anti-diabetic activity of Centaurium umbellatum (CU) in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced by a single intraperitoneal injection of STZ (65 mg/kg bw). Normal and diabetic rats were treated with CU aqueous leaf extract, at a dose of 200 mg/kg bw, for 4 weeks. Serum glucose and insulin concentrations, hepatic glycogen c...

Amongst the numerous co-adjuvant therapies which could influence the incidence and progression of diabetic complications, antioxidants and flavonoids are currently being tested in clinical trials. We investigated the effect of naringerin on biochemical parameters in streptozotocin-induced (STZ 60 mg/kg, i.p.) diabetic rats. Male rats were divided into four groups: G1: untreated controls; G2: no...