The title Schiff base compound, C15H17N3O2S, is non-planar with a dihedral angle of 69.88 (4)° between the planes of the benzene rings. In the crystal, pairs of N-H⋯N hydrogen bonds, between the sulfonamide nitro-gen-H atom and the azomethine N atom, link the mol-ecules into inversion dimers, forming R 2 (2)(16) ring motifs. These dimers are linked by N-H⋯O hydrogen bonds, between the sulfonami...

In the title compound, C17H17N3O3 (.)0.5H2O, the indazole system makes a dihedral angle of 46.19 (8)° with the plane through the benzene ring and is nearly perpendicular to the allyl group, as indicated by the dihedral angle of 81.2 (3)°. In the crystal, the water mol-ecule, disordered over two sites related by an inversion center, forms O-H⋯N bridges between indazole N atoms of two sulfonamide...

Glutamate synthase, isolated in apparently homogeneous form (Mr approximately 265,000) from Saccharomyces cerevisiae after 7500-fold purification, is markedly inhibited by homocysteine sulfonamide. Inhibitions competitive with respect to L-glutamine; the apparent Ki value calculated for L-homocysteine sulfonamide is 3.6 microM; the apparent Km value for L-glutamine is 280 microM. The very high ...

It is important for the prevention and treatment of colibacillosis to monitor drug resistance in Escherichia coli. To choose effective drugs to prevent and control avian colibacillosis in North China, we investigated the resistance of 164 E. coli isolates (from Beijing, Tianjin, Inner Mongolia, Shanxi, and Hebei regions of China) to commonly used clinical sulfonamide antibiotics using a drug su...

N,N-dichloropolystyrene sulfonamide as a decontaminant was synthesized in 5 steps from styrene monomer. Styrene was first polymerized. Then, sulfonation reaction was performed by H2SO4 (c) followed by chlorination with POCl3 obtain chlorosulfonated polystyrene. Amidification reaction was then applied to get sulfonamide resin. Sulfonamide resin was treat...

A flexible and short synthesis of sulfonamide-bridged di-, tri-, tetra-, and octasaccharide glycomimetics was accomplished by reaction of glycosyl thioacetates with amino sugar substrates. The chemistry to incorporate the sulfonamide linker in place of a native O-glycosidic bond was broadly scoped, allowing access to head-to-head (1↔1) and head-to-tail (1→2), (1→3), (1→4), and (1→6) sulfonamide...

A feature of sulfonamide therapy for bacterial infections is that species of bacteria differ in their resistance to the antibacterial action of the compounds. It is also recognized that strains of microorganisms within the same species display variations in susceptibility. A disconcerting and confusing factor associated with chemotherapy, which appears to be assuming increasing clinical signifi...

3 0 9 (celecoxib and valdecoxib) could possibly cross react with sulfonamides. The sulfonamide-type reactions (erythema multiforme, Stevens Johnson syndrome, toxic epidermal necrolysis (TEN) and maculopapular rash) were found to be twice as common with celecoxib as with rofecoxib. The pathogenesis of these reactions is likely to be the same as for sulfonamide induced reactions – T cell mediated...

In the title solvate, C(11)H(11)N(3)O(2)S·CH(3)NO(2), the dihedral angle between the benzene ring and the N-containing ring is 85.94 (11)°, and an approximate V shape arises for the sulfonamide mol-ecule. In the crystal, N-H⋯O and N-H⋯N hydrogen bonds and weak C-H⋯O inter-actions link the sulfonamide mol-ecules into a three-dimensional network. The nitro-methane solvent mol-ecules are located i...