Adverse drug reactions are a major problem complicating medical therapy. The pathogenesis of many severe adverse drug reactions, notably hypersensitivity reactions, is poorly understood. The sulfonamides are associated with severe hypersensitivity reactions. The initial pathogenesis seems to be caused by bioactivation of the parent drug to a reactive intermediate and subsequent propagation by t...

The title compound, C(12)H(12)N(2)O(2)S, was obtained by the reaction of 2-mercaptopyridine and benzyl-amine. The dihedral angle between the benzene and pyridine rings is 75.75 (9)°. In the crystal, mol-ecules are linked into chains along the c axis by N-H⋯O and N-H⋯N hydrogen bonds; the chains are cross-linked into a two-dimensional network parallel to the bc plane via C-H⋯O hydrogen bonds.

Chalcones, or 1,3–diaryl–2–propen–1–ones, one of the major classes of natural products and posses many useful properties like anticancer, antibacterial, antifungal, anti–inflammatory, antimalarial and anti–diabetic activity. We report in this communication the synthesis and anticancer study of a number of novel chalcone sulfonamides. Our results indicate that the synthesis of chalcone sulfonami...

Chalcones, or 1,3–diaryl–2–propen–1–ones, one of the major classes of natural products and posses many useful properties like anticancer, antibacterial, antifungal, anti–inflammatory, antimalarial and anti–diabetic activity. We report in this communication the synthesis and anticancer study of a number of novel chalcone sulfonamides. Our results indicate that the synthesis of chalcone sulfonami...

The genetic basis of sulfonamide resistance in six clinical isolates of Streptococcus pneumoniae was demonstrated to be 3- or 6-bp duplications within sulA, the chromosomal gene encoding dihydropteroate synthase. The duplications all result in repetition of one or two amino acids in the region from Arg58 to Tyr63, close to but distinct from the sul-d mutation, a duplication previously reported ...

Hypoxic microenvironment is a common situation in solid tumors. Carbonic anhydrase IX (CA9) is one of the reliable cellular biomarkers of hypoxia. The role of CA9 in colorectal cancer (CRC) remains to be clarified. CA9 inhibitor such as sulfonamides is known to block CA9 activation and reduce tumor growth consequently. Here, we aimed to investigate the CA9 expression in serum and tumor from dif...

Membrane-permeable and impermeable inhibitors of carbonic anhydrase have been used to assess the roles of extracellular and intracellular carbonic anhydrase on the inorganic carbon concentrating system in Chlamydomonas reinhardtii. Acetazolamide, ethoxzolamide, and a membrane-impermeable, dextran-bound sulfonamide were potent inhibitors of extracellular carbonic anhydrase measured with intact c...

1. Sulfonamide chemotherapy controls the bacterial component of combined infection with influenza virus and pneumococci in rats. 2. Reinstillation of fluid (broth, physiological salt solution) into the respiratory passages of mice several days after sublethal viral infection converts the viral infection into a lethal one. 3. Sulfonamide chemotherapy controls the bacterial component of combined ...

1. In vitro experiments were performed with E. coli, using a method designed for the quantitative study of various aspects of sulfonamide resistance. 2. Resistance was found to be a gradually developing process, and was demonstrated for all four drugs tested, sulfanilamide, sulfapyridine, sulfathiazole, and sulfadiazine. 3. It was shown that the degree of resistance developed was correlated wit...

Sulfonamide antibiotics are a commonly used group of compounds in animal husbandry. They are excreted with manure, which is collected in a storage lagoon in certain types of confined animal feeding operations. Flood irrigation of forage fields with this liquid manure creates the potential risk of groundwater contamination in areas with shallow groundwater levels. We tested the hypothesis that-i...