PURPOSE The process of invasion and metastasis formation of tumor cells can be studied by following the migration of labeled cells over prolonged time periods. This report investigates the applicability of iron oxide nanoparticles as a magnetic resonance imaging (MRI) contrast agent for cell labeling. METHODS γFe2 O3 nanoparticles prepared with direct flame spray pyrolysis are biofunctionaliz...

Introduction Magnetic resonance imaging is a powerful tool for visualizing cellular/macrophage tracking and migration or inflammatory processes. MRI examinations can be performed longitudinally and non-invasively, at isotropic image resolutions approaching 50 microns within reasonable scan times in live animals. Whereas vascular and interstitial compartments are investigated using Gadolinium-ba...

in this study we report the rock magnetic properties of surface soil samples and their spatialvariability from the northernmost district of kerala to understand pedogenic processes and soil erosion. themagnetic signal is mainly from fine grained pedogenic magnetite as other sources like anthropogenic andlithogenic magnetite, bacterial magnetite and greigite are absent. the surface soil samples ...

Monodisperse small iron oxide nanoparticles functionalized with dendritic polyglycerol (dPG) or dendritic polyglycerol sulfate (dPGS) are prepared. They are highly stable in aqueous solutions as well as physiological media. In particular, oleic acid capped iron oxide particles (core diameter = 11 ± 1 nm) were modified by a ligand exchange process in a one pot synthesis with dPG and dPGS bearing...

INTRODUCTION Super-paramagnetic iron oxide (SPIO) particles can label macrophages and monocytes in circulation; the effects of these labeled cells can then be detected by T2*-weighted MRI [1]. This has enormous potential for imaging inflammatory responses in the heart, but it has been difficult to do in vivo using conventional methods for free-breathing, ungated imaging. Subspace imaging with t...

We propose a novel combination of methods to study the physical properties of ferric ions and iron-oxide nanoparticles in post-mortem human brain, based on the combination of Electron Paramagnetic Resonance (EPR) and SQUID magnetometry. By means of EPR, we derive the concentration of the low molecular weight iron pool, as well as the product of its electron spin relaxation times. Additionally, ...

Purpose: The presence of tumor-associatedmacrophages (TAM) in breast cancer correlates strongly with poor outcome. The purpose of this study was to develop a clinically applicable, noninvasive diagnostic assay for selective targeting and visualization of TAMs in breast cancer, based on magnetic resonanceI and clinically applicable iron oxide nanoparticles. Experimental Design: F4/80-negativemam...

Background: Despite the wide range of applications, there is a serious lack of information on the impact of the nanoparticles on human health and the environment. The present study was done to determine the range of dangerous concentrations of iron oxide nanoparticle and their effects on mouse embryonic stem cells. Methods: Iron oxide nanoparticles with less than 20 nanometers diameter were en...

fe3o4 nanostructures were synthesized via a facile hydrothermal reaction. the effect of various surfactants such as cationic and anionic on the morphology of the product was investigated. magnetic nanoparticles were added to poly styrene (ps) for preparation of magnetic nanocomposite. nanostructures were then characterized using x-ray diffraction (xrd), scanning electron microscopy (sem) and fo...