Five siblings of a Danish family with slowly progressive involvement of the trigeminal, facial, glossopharyngeal, accessory, and hypoglossal nerves beginning at the age of 55-65 years were examined. All had asymptomatic corneal lattice dystrophy. Clinical and electrophysiological investigations also showed evidence of slight neurogenic involvement of the limbs. Conduction velocity along sensory...

OBJECTIVE To evaluate postganglionic autonomic and somatic nerve fiber involvement in a patient with chronic autoimmune autonomic ganglionopathy. DESIGN Case report. SETTING Department of Neurological Sciences, University Federico II of Naples. PATIENT A patient with a 16-year history of severe autonomic failure and a high nicotinic acetylcholine receptor antibody titer underwent an exten...

Aldose reductase inhibitors improve nerve biochemistry, function, and structure in diabetic animals and increase nerve conduction in diabetic patients. Nevertheless, it has been difficult to demonstrate a benefit from these agents in patients with clinically overt diabetic neuropathy. Direct measurement of the nerve tissue penetration and biochemical and biological potency of these compounds is...

OBJECTIVE Repair of sensorial nerve defect is an important issue on peripheric nerve surgery. The aim of the present study was to determine the effects of sensory-motor nerve bridging on the denervated dermatomal area, in rats with sensory nerve defects, using a neural cell adhesion molecule (NCAM). METHODS We compared the efficacy of end-to-side (ETS) coaptation of the tibial nerve for sural...

Changes with age in internodal length in the sural nerve in man have been discussed by Lascelles and Thomas (1966). They reported their findings in the sural nerve obtained at necropsy in 14 subjects of ages ranging from 18 to 80 years. In the 10 subjects under the age of 65 years the correlation between internodal length and the maximum diameter of single nerve fibres was found to be close, es...

Surgical treatment for recurrent, common peroneal neuropathy has not been reported. Herein, we describe a successfully treated case using the proximally based sural fasciocutaneous flap after reneurolysis of the adhesive common peroneal nerve. A 33-year-old man received a neurolysis operation for entrapment neuropathy of the common peroneal nerve 2 years before first admission in our clinic. Al...

The extent of the influence of the transverse distance between surface recording electrodes and the lateral antebrachial cutaneous and sural nerves when performing orthodromic recordings of sensory nerve action potential amplitudes was investigated on 60 healthy volunteers, using a stringent protocol. The recording electrodes were positioned on top of the studied nerves and per 5 mm to each sid...

The cardio-ankle vascular index (CAVI) is used to test vascular function and is an arterial stiffness marker and potential predictor of cardiovascular events. This study aimed to analyze the relation between objective indices of diabetic polyneuropathy (DPN) and the CAVI. One hundred sixty-six patients with type 2 diabetes mellitus were included in this study. We used nerve conduction studies (...

BACKGROUND AND PURPOSE Although spinal root abnormalities are known to occur, spinal MR examination is seldom performed in hereditary motor and sensory neuropathies (HMSN). The following work was undertaken to assess the MR imaging spectrum of lumbosacral spinal nerve root abnormalities and determine whether intradural nerve root involvement could be related to any biopsy feature. METHODS Ten...