A sensitive and label-free analytical approach for the detection of porcine circovirus type 2 (PCV2) instead of PCV2 antibody in serum sample was systematically investigated in this research based on surface plasmon resonance (SPR) with an establishment of special molecular identification membrane. The experimental device for constructing the biosensing analyzer is composed of an integrated bio...

Surface plasmon resonance (SPR) biosensors are affinity sensing devices exploiting a special mode of electromagnetic field-surface plasmon-polariton-to detect the binding of analyte molecules from a liquid sample to biomolecular recognition elements immobilized on the surface of the sensor. In this paper, we review advances of SPR biosensor technology towards detection systems for the simultane...

Surface plasmon resonance (SPR) imaging sensors realize label free, real-time, highly sensitive, quantitative, high throughput biological interaction monitoring and the binding profiles from multi-analytes further provide the binding kinetic parameters between different bio-molecules. In the past two decades, SPR imaging sensors found rapid increasing applications in fundamental biological stud...

Frequency combs, millions of narrow-linewidth optical modes referenced to an atomic clock, have shown remarkable potential in time/frequency metrology, atomic/molecular spectroscopy and precision LIDARs. Applications have extended to coherent nonlinear Raman spectroscopy of molecules and quantum metrology for entangled atomic qubits. Frequency combs will create novel possibilities in nano-photo...

Most of the optical sensors based on surface plasmon resonance (SPR) are imitated from two main configurations. Firstly, in the KretschmannRaether configuration, a thin metal layer is sandwiched between the prism and the air. Otherwise, the Otto configuration, there is a gap between the metal and the prism. However, the Kretschmann-Raether geometry is more conventional scheme to generate the su...

Design and Simulation of Graphene/2D Interlayer Surface Plasmon Resonance Biosensor Based on Ellipsometry Method

The Surface Plasmon Resonance (SPR) technique makes it possible to measure biomolecular interactions in real-time with a high degree of sensitivity and without the need of label. The information obtained is both qualitative and quantitative and it is possible to obtain the kinetic parameters of the interaction. This new technology has been used to study a diverse set of interaction partners of ...

The combined use of surface plasmon resonance (SPR) and modified or mimic oligonucleotides have expanded diagnostic capabilities of SPR-based biosensors and have allowed detailed studies of molecular recognition processes. This review summarizes the most significant advances made in this area over the past 15 years.   Functional and conformationally restricted DNA analogs (e.g., aptamers an...

We elucidated the distance-dependent plasmonic effects on radiative transitions from an Eu(3+) ion-doped phosphor by varying the thickness of the dielectric spacer. Magnesium oxide prepared by electron-beam evaporation was chosen for the dielectric spacer. Spectral overlap between emission from Eu(3+) ions and the plasmon band of Ag nanoparticles led to improved luminescence intensity. This lum...