an ultrasound-assisted surfactant-enhanced emulsification microextra- ction (uaseme) coupled with high performance liquid chromatography-diode array detection has been developed for the extraction and determination of thiopental in serum and urine samples. a simple microextraction method based on emulsification of organic extraction solvent in aqueous sample using an ionic surfactant and withou...

STUDY OBJECTIVES To determine whether chronic lung inflammation in young adult patients with cystic fibrosis (CF) alters the composition and function of surfactant and surfactant components in bronchoalveolar secretions. DESIGN A prospective, descriptive study. SETTING An adult CF center in a tertiary health-care center. PARTICIPANTS Thirteen normal volunteer (NV) subjects recruited via l...

Pulmonary surfactant is a complex mixture of phospholipids and proteins, which is present in the alveolar lining fluid and is essential for normal lung function. Alterations in surfactant composition have been reported in several interstitial lung diseases (ILDs). Furthermore, a mutation in the surfactant protein C gene that results in complete absence of the protein has been shown to be associ...

At low concentrations, surfactant molecules are unassociated monomers. As the concentration of surfactant is increased, the attractive and repulsive forces between the molecules cause self-aggregation to occur resulting in the formation of monolayers or micelles (Figure 1). The concentration at which these micelles form is called the critical micelle concentration (cmc). The characteristics of ...

Complexes obtained from the electrostatic interactions between chitosan, a cationic polysaccharide, and sodium decylsulfonate, an anionic surfactant, were characterized by their conductimetric and surface-active properties. Such surfactant/polyelectrolyte complexes (SPECs) present very interesting surface-active properties, even at very low surfactant concentrations (much lower than the critica...

BACKGROUND Mechanical ventilation (MV) is an essential supportive therapy for acute lung injury (ALI); however it can also contribute to systemic inflammation. Since pulmonary surfactant has anti-inflammatory properties, the aim of the study was to investigate the effect of exogenous surfactant administration on ventilation-induced systemic inflammation. METHODS Mice were randomized to receiv...

The present work was conducted on the effect of surfactant on the dissolution rate of ibuprofen tablets. The cationic (Cetyl Trimethyl bromide) and anionic (Sodium dodecyl sulphate) surfactant present in the dissolution media have remarkable effect on the dissolution rate of Ibuprofen. Maximum dissolution was obtained in the presence of anionic surfactant (Sodium dodecyl sulphate) at 0.5% conce...

Using a hydrodynamic lattice-gas model, we study interface growth in a binary fluid with various concentrations of surfactant. We find that the interface is smoothed by small concentrations of surfactant, while microemulsion droplets form for large surfactant concentrations. To assist in determining the stability limits of the interface, we calculate the change in the roughness and growth expon...

Lung surfactant is a complex mixture of lipids and proteins, which is secreted from the alveolar type II epithelial cell and coats the surface of alveoli as a thin layer. It plays a crucial role in the prevention of alveolar collapse through its ability to reduce surface tension. Under normal conditions, surfactant homeostasis is maintained by balancing its release and the uptake by the type II...

We searched the MEDLINE, CINAHL, and Cochrane Library databases for English-language randomized controlled trials, systematic reviews, and articles investigating surfactant replacement therapy published between January 1990 and July 2012. By inspection of titles, references having no relevance to the clinical practice guideline were eliminated. The update of this clinical practice guideline is ...