BACKGROUND In animals with acquired surfactant-deficiency, a recruitment maneuver by increased tidal volumes enhances the effect of exogenous surfactant. In contrast, in the preterm lamb model, hyperinflation early after birth impairs the effect of surfactant prophylaxis. Here we examined whether a lung recruitment maneuver just before surfactant would affect the response to rescue treatment in...

BACKGROUND This study examines the biophysical and preclinical pulmonary activity of synthetic lung surfactants containing novel phospholipase-resistant phosphonolipids or synthetic glycerophospholipids combined with Super Mini-B (S-MB) DATK and/or SP-Css ion-lock 1 peptides that replicate the functional biophysics of surfactant proteins (SP)-B and SP-C. Phospholipase-resistant phosphonolipids ...

The sal inity tolerance (precipitation phase boundary) is measured for a mixed anionic/nonionic surfactant sy s t em above the CMC. For any total surfactant concentration, the salinity tolerance is shown to increase as the percentage of nonionic surfactant in the s y s t e m is increased. A model is developed which can predict the phase houndaries for the mixed surfactant s y s t e m from the p...

The binding of an anionic surfactant onto an anionic surface by addition of divalent ions is reported based on experimental data from specular neutron reflection (NR) and attenuated total internal reflection IR spectroscopy (ATR-IR). Similar measurements using monovalent ions (sodium) do not show any evidence of such adsorption, even though the amount of surfactant can be much higher. This data...

The modulational instability (MI) of ion-acoustic waves (IAWs) is examined theoretically in a four-component plasma system containing inertialess electrons featuring non-thermal, non-extensive distribution, iso-thermal positrons, and positively as well negatively charged inertial ions. In this connection, non-linear Schrödinger equation (NLSE), which dominates the conditions for MI associated w...