This paper presents the combined technologies, rheology, zeta potential and particle size measurements, that are important to characterize particle suspensions. We will use a system that sediments at room temperature and explain why different techniques are needed to characterize the system to show its potential stability INTRODUCTION Suspensions or dispersions of particles or droplets in a liq...

Available tablets or capsules for adults are often used to prepare extemporaneously formulated medicines appropriate for children. The most acceptable drug forms in pediatric population are oral liquids and pharmacists use commercial dispersing media to compound syrups from an active substance or from tablets available on the market. In many countries ready-to-use dispersing media are not avail...

The effect of shear force (depending on shear rate and viscosity of extracellular medium) and hematocrit of RBC suspension on RBC deformation was studied quantitatively using a cone-plate rheoscope with various kinds of cells, ie, partially hemolyzed (PH) cells, density-fractionated intact cells, and diamide-treated cells. The deformation index (DI) of ellipsoidally deformed cells was shown to ...

Sheets of mucosal epithelial cells were released from guinea pig small intestine after incubation with ethylenediaminetetraacetate. Cells in sheets retained their columnar shape for 24 hr at room temperature, and exclusion of nigrosine suggested they had intact plasma membranes. When sheets were disaggregated individual cells had normal morphology for at least 4 hr. During isolation 16% of the ...

Measurements are reported of the number of H+ translocated from the matrix to the suspending medium as a pair of electrons passes through energy-conserving Site 2, as reflected by electron flow from succinate to the artificial electron acceptor ferricyanide in intact rat liver mitochondria. The reduction of ferricyanide was measured by dual wavelength spectrophotometry and the translocation of ...

1. Respiration and fermentation of yeast receiving 90,000 r of 250 kv. x-rays were studied under a variety of conditions. This dose will nearly completely inhibit growth or colony formation. 2. The apparent effects of irradiation are quite dependent on the K(+) and H(+) of the suspending medium. At pH 4.5 stimulatory effects were observed in KH(2)PO(2) buffer and inhibition in potassium-free (T...

Suspension dosage forms require the use of suspending agents in order to deliver a uniform dose of the active ingredient. The purpose of this study is to investigate the properties of a new plant gum as a cheap and effective natural polymer in the formulation of pharmaceutical suspensions. The gum obtained from the incised trunk of Cedrela odorata (family Meliaceae) was compared with hydroxypro...

Oseltamivir (Tamiflu) is widely prescribed to treat and prevent influenza virus A, influenza virus B, and H1N1 Flu. It is manufactured by Roche in 75-mg capsules. The need for other administration options for patients who cannot take capsules and cannot use suspending agents which contain alcohol, sorbitol, or preservatives has led to the compounding of oseltamivir into three suspending vehicle...