s | 43 nights of wrist actigraphy. The mean age was 54.3 years (range 34 to 83). To reveal factors associated with insulin resistance and age, statistically significant variables in univariate regression analyses were entered into multivariate regression analyses. Insulin resistance was estimated by homeostasis model assessment of insulin resistance (HOMA-IR). In women, higher sleep onset laten...

Fifteen years after the discovery of hypocretin/orexin a large body of evidence has been collected supporting its critical role in the modulation of several regulatory physiological functions. While reduced levels of hypocretin/orexin were initially associated with narcolepsy, increased levels have been linked in recent years to pathological states of hypervigilance and, in particular, to insom...