One decade ago, our laboratory provided the first direct evidence linking orexin/hypocretin signaling with drug seeking by showing that activation of these neurons promotes conditioned morphine-seeking behavior. In the years since, contributions from many investigators have revealed roles for orexins in addiction for all drugs of abuse tested, but only under select circumstances. We recently pr...

Introduction Primary insomnia is frequently present in the general population, with epidemiologic research reporting prevalence values from 10% to as high 60%. Chronic associated a significant impact on professional, academic, and daily life functionality, it also may be responsible for decreasing quality of life. Multiple generations drugs have been launched clinical use last decades, but each...