This article presents a case-study review of synergy concepts of nonlinear blending and dose-reduction profiles. "Strong nonlinear blending" is a novel concept that provides a flexible paradigm for the assessment of combination drug synergy that is applicable to any shaped combination-drug dose-response surface; issues of varying relative potency, partial inhibitors, potentiation, or coalism po...

In spite of the vast literature on spreading dynamics on complex networks, the role of local synergy, i.e., the interaction of elements that when combined produce a total effect greater than the sum of the individual elements, has been studied but only for irreversible spreading dynamics. Reversible spreading dynamics are ubiquitous but their interplay with synergy has remained unknown. To fill...

Williams and Beer (2010) proposed a nonnegative mutual information decomposition, based on the construction of information gain lattices, which allows separating the information that a set of variables contains about another variable into components, interpretable as the unique information of one variable, or redundant and synergy components. In this work, we extend this framework focusing on t...

BACKGROUND Renal cell carcinoma (RCC) is one of the most common kidney cancers and is highly resistant to chemotherapy. We previously demonstrated that 5-aza-2'-deoxycytidine (DAC) could significantly increase the susceptibility of renal cell carcinoma (RCC) cells to paclitaxel (PTX) treatment in vitro, and showed the synergy of DAC and PTX against RCC. The purpose of this study is to investiga...

This article describes a method for constructing a special rule (we call it synergy rule) that uses as its input information the outputs (scores) of several monotonic rules which solve the same pattern recognition problem. As an example of scores of such monotonic rules we consider here scores of SVM classifiers. In order to construct the optimal synergy rule, we estimate the conditional probab...

Analysis of the impact of architecture model of cluster management on the strategy of its innovative and investment development, ongoing innovation activities, the growth of innovative capacity and effectiveness of development projects due to the appearance of architectural synergy. Key-Words: industrial cluster architecture, business architecture, IT architecture, cluster development projects,...

Synergy between sulphadiazine and trimethoprim against Escherichia coli has been demonstrated in culture media not containing lysed horse blood despite the presence of pus or a pus extract which inhibited the action of each drug separately. Synergy may therefore be important where pus is present in vivo.