Drug synergy allows a therapeutic effect to be achieved with lower doses of component drugs. Drug synergy can result when drugs target the products of genes that act in parallel pathways ('specific synergy'). Such cases of drug synergy should tend to correspond to synergistic genetic interaction between the corresponding target genes. Alternatively, 'promiscuous synergy' can arise when one drug...

ObjectiveThe present work represents the green synthesis of silver nanoparticles using Withania coagulans extract and its antibacterial property. The synergy, additive, bacteriostatic and bactericidal effect of silver nanoparticles was determined against Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Salmonella typhi, and Vibrio cholerae. Methods <...

language is primarily constituted by action and interaction based on sensorimotor information. this paper demonstrates the nature of subjectivity and intersubjectivity through the neural mechanism and typological evidence of sentence-final particles from east asian languages and extends to the discussion of the relationship between them. i propose that intersubjecivity is a kind of embedded or ...

We studied the interaction between rifampin and fusidic acid against a group of staphylococci. Of the 20 coagulase-positive strains studied, checkerboard studies revealed synergy in 3 and indifference in 17; time-kill studies revealed synergy in 18 of 19 coagulase-positive strains at both 24 and 48 h. Of the 19 coagulase-negative strains, checkerboard studies revealed synergy in 6 and indiffere...