background: paraoxonase-1(pon1), a high-density lipoprotein (hdl) associated enzyme, is believed to contribute in the patho­genesis of coronary artery disease (cad). the aim of this study was to evaluate the association of pon1 promoter c (-107)t polymorphism with the extent of coronary artery stenosis in iranian patients. methods : the rflp analysis for determination of the c(-107)t genotype d...

BACKGROUND The Gγ-158(C→T) polymorphism plays important function in the clinical variability of HbE/β-thalassemia. There is little known about Gγ-158(C→T) polymorphism in HbE/β-thalassemia major in Southern China. This study aimed to explore the association between HbE/β-thalassemia major and this polymorphism in Southern China. METHODS AND RESULTS The frequency of the Gγ-158(C→T) polymorphis...

Single-Nucleotide Polymorphism of rs11061971 (+219 A>T) in Adiponectin Receptor 2 (AdipoR2) Gene and its Association with Risk Type Diabetes among Iranian Population

Several investigations have focused on the relationship between paraoxonase-1 (PON-1) polymorphisms and the risk of polycystic ovary syndrome (PCOS); however, the result remains conflicting. To obtain a more precise estimation of the correlation between PON-1 polymorphisms [rs705379 C>T (-108C/T), rs854560 T>A (55Leu/ Met) and rs662 A>G (192Gln/Arg)] and the risk of PCOS, we performed a meta-an...

BACKGROUND Prohibitin 3' untranslated region 1630 C>T (rs6917) polymorphism creates a variant T allele that lacks the antiproliferative activity of the more common functional C allele. Previous studies indicate that women carrying the prohibitin T allele have an increased susceptibility to breast cancer. However, the role of 1630 C>T polymorphism in mRNA expression of prohibitin and its contrib...

background: pulmonary tuberculosis (ptb) has recently become a major problem in developed countries especially in immune compromised hiv infected individuals. cytokines, their genes and receptors have been implicated in the protective immunity, pathophysiology and development of tuberculosis.   material & methods: in the present study the genotype frequencies of a number of polymorphic genes co...

The T-786C promoter and 27-bp repeat intron 4 polymorphisms in the endothelial NO synthase (eNOS) gene have been inconsistently associated with various eNOS-related phenotypic changes. We explored molecular mechanisms underlying the inconsistency. We constructed pGL3 luciferase reporter vectors by inserting an eNOS promoter fragment containing either T or C nucleotide at -786 bp at the 5' end o...

DNA polymorphism within diacylglycerol transferase 2 (DGAT2) / monoacyl glycerol transferases 2 (MOGAT2), leptin and butyrophilin genes were analysed using PCR-SSCP in Murrah buffalo. The single strand conformation polymorphism (SSCP) analysis of amplified gene fragment in exon 5 of MOGAT2, exon 3 of leptin and intron 1 of butyrophilin gene revealed different patterns. A, B and C showed the fol...