In this paper, extensive three-dimensional finite element analysis is conducted to study an asymmetric four-point shear (AFPS) specimen: a widely used mixed-mode I/II fracture test specimen. Complete solutions of mechanics parameters KI, KII, KIII, T11, and T33 have been obtained for wide range a/W t/W geometry combinations. It demonstrated that the thickness specimen has significant effect on ...

Recurrent HSV-1 ocular disease results from reactivation of latent virus in trigeminal ganglia, often following immunosuppression or exposure to a variety of psychological or physical stressors. HSV-specific CD8+ T cells can block HSV-1 reactivation from latency in ex vivo trigeminal ganglia cultures through production of IFN-gamma. In this study, we establish that either CD8+ T cell depletion ...

In order to study the effects of salinity stress on growth indices of three clover species including, Trifolium resupinatum, T. alexandrinum, and T. incarnatum, an experiment was conducted as factorial based on a completely randomized design arrangement with three replications. Factors included seven levels of salinity stress (0, 41, 82, 123, 164, 205, and 246 mM) and three clover species. Diff...

Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (ox-PAPC), a component of minimally modified low density lipoprotein, induces monocyte adhesion to endothelial cells. It is not known whether the upstroke slopes of pulsatile flow, defined as shear stress slew rates (tau(r)/tauT)), can regulate monocyte binding to ox-PAPC-treated bovine aortic endothelial cells (BAECs). At 60 cy...

b = a length L c = the cohesion intercept M L T Ip = the plasticity index P = a force M L T u = the pore fluid pressure ML T θ = an angle Angle μ1 = shear strength reduction factor related to time effects μ2 = shear strength reduction factor related to fissuring σ = the normal stress on a plane M L T τ = the shearing stress on a plane M L T φ = the angle of internal friction Angle ψ = an angle ...

OBJECTIVES We sought to separate the effects of associated left bundle branch block (LBBB) and coronary artery disease (CAD) on peak cardiac output (CO) during dobutamine stress in patients with dilated cardiomyopathy (DCM). BACKGROUND The mechanisms limiting CO during stress in patients with DCM are unclear. Both LBBB and CAD may do so by prolonging the total isovolumic time (t-IVT). METHO...

Corticotropin-releasing factor (CRF), encoded by the CRH gene, is a key integrator of stress responses, and, as such, CRH gene variation may contribute to individual differences in susceptibility to stress-related pathology. In rhesus macaques, a single nucleotide polymorphism (SNP) is found within the CRH promoter (-248C--> T). Here, we assessed whether this variant influenced stress respondin...

The equivalent body forces for a stress-drop seismic source are found. When the isotropic stress drop and one of the three principal stress drops are zero, then the equivalent body forces are the same double couple without moment which would result from a shear dislocation. In general however, all six stress-drop components must be specified as independent functions of time. THE STRESS-DROP SOU...