Inherited thyroxine binding globulin (TBG) disorder can be identified incidentally or through neonatal screening test. TBG excess is characterized by high levels of thyroxine (T4) but normal level of free T4 (fT4), while TBG deficiency presents with low T4 levels and normal fT4 levels. A 27-day-old newborn was brought to the hospital because of hyperthyroxinemia detected by neonatal screening. ...

In 18 cases of serious and fairly serious toxemic pregnancy, the authors gave 500 micrograms L-Thyroxin "Henning" intraamniotically after the laboratory evaluation demonstrated negative pulmonary maturity from an amniotic fluid sample. Maternal and fetal complications due to the drug could not be observed. Despite a 39% premature incidence, IRDS and hyaline membrane disease were not observed. T...

The goal of this study was to establish Magnetic resonance imaging (MRI) reference ranges for spinal measurements in normal dogs. Forty dogs (1-10 kg, 11-20 kg, 21-30 kg, > 30 kg; 10 dogs per category) underwent spinal MRI. Measurements were performed on sagittal T2-W images at the level of the 4th thoracic vertebra (T4), the 9th thoracic vertebra (T9) and the 3rd lumbar vertebra (L3). Spinal c...

Background and Aims: 25-hydroxy vitamin D3 is recognized to be an essential element for healthy body; however, its deficiency has been identified as a risk factor for thyroid disease, diabetes mellitus and other autoimmune diseases and infectious diseases. Thyroid disease is common in the general population that its prevalence increases proportional to age. Subjects with poorly controlled diabe...

background and objective: thyroid function problems are often present with prematurity disorders. thyroid hormones regulate growth and distinguish body organs; especially they affect central nervous system and metabolism of carbohydrates, lipids, and vitamins. thus, these hormones should be evaluated. the present study aims to determine the mean level of thyroid hormones among premature infants...

Serum thyroid hormone levels have been assayed to evaluate the thyroid hormonal function in Vitiligo patients of Bangladesh. The levels of TSH, T3 and T4 in the serum of Vitiligo patients have been analyzed in both the male and female subjects. Results of hormonal assay indicated that some hormonal changes occurred in the Vitiligo patients as compared with the healthy control. In female Vitilig...

The plasma triiodothyronine (T3) and thyroxine (T4) ratios have been evaluated in kwashiorkor and diet-induced obese weaned rats. The concentrations of T3 and T4 were determined in plasma by radio-immunoassay. A significant decrease in T3 level in the order kwashiorkor < obese < control was observed. However T4 concentration was more elevated (P < 0.01) in the obese than the normal controls, wh...

BACKGROUND Endocrine disrupting chemicals (EDCs) present in the environment may disrupt thyroid hormones, which in early life are essential for brain development. Observational studies regarding this topic are still limited, however as the presence of chemicals in the environment is ubiquitous, further research is warranted. The objective of the current study was to assess the association betwe...

Objective: The aim of the present study was to compare the effects of Portulaca oleracea (Po) seeds extract and those of valsartan on cardiac function in levothyroxine (T4)-treated rats. Materials and Methods: Forty Wistar rats were divided into four groups (n=10): control, levothyroxine (T4), T4 plus valsartan (T4-Val) and T4 plus hydro-alcoholic extract of the P. oleracea seeds (T4-Po). Contr...

Phage T4, the archetype of lytic bacterial viruses, needs only 62 genes to propagate under standard laboratory conditions. Interestingly, the T4 genome contains more than 100 putative genes of unknown function, with few detectable homologues in cellular genomes. To characterize this uncharted territory of genetic information, we have identified several T4 genes that prevent bacterial growth whe...