The antidepressant-like effects of N-palmitoylethanolamide (PEA), a putative endocannabinoid, was investigated in mice using the tail suspension test (TST) and the forced swimming test (FST). In TST, PEA (10, 20, and 40 mg/kg) produced a statistically significant reduction in immobility (50, 32, and 34%, respectively, vs. the control group), whereas fluoxetine (20 mg/kg) reduced immobility by 3...

OBJECTIVE Pediatric depression is associated with significant functional impairment at school and at work. Recently, we reported on depression-like behavior in juvenile mice neonatally exposed to dexamethasone (DEX) as a potential animal model for pediatric depression. The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has promoted rapid and long-lasting antidepressant effects in pati...

Aim: This study aims to determine the activity, capacity of macrophage phagocytosis, and percentage leukocyte cells male mice treated with ethanol extract moringa leaves (Moringa oleifera Lam). Methods: Twenty were divided into four equal groups. The was administered orally for seven days at a dose 10; 30; 100 mg/kg; 0.5% CMC Na suspension as negative control. On 8th day, blood cell leukocytes ...

The depressant activity of trimyristin and its interaction with antidepressants like amitryptiline, imipramine, mianserin, and fluoxetine has been studied. In forced swim tests and tail suspension tests male albino mice were treated intraperitoneally with 10 mg/kg each of amitryptiline, imipramine, mianserin, and fluoxetine 30 min before vehicle or trimyristin (10 or 30 mg/kg i.p.). Some groups...