OBJECTIVES To assess the effect of cigarette smoking on lipid peroxidation induced oxidative stress, antioxidants, uric acid and blood sugar in normal subjects. METHODS The study included 61 normal subjects with regular smoking habit and 57 never-smokers normal subjects matched in respect to socio-economic status, age and BMI. Information regarding smoking habit and other personal details wer...

The susceptibility of meats from different animal species (chicken breast [CB] and thigh [CT], pork [PL and beef [BL]) to lipid oxidation was studied. The amounts of TBARS in raw PL, CB, and CT did not change during a 7-d storage period. TBARS values of raw BL, however, significantly increased during 7-d storage because of high heme iron content, high lipoxygenase-like activities, and low 1,1-d...

Dibromoacetonitrile (DBAN) is a water disinfection by-product. The objective of the present work was to investigate the cytotoxic effects as well as the oxidative stress induced by DBAN in cultured rat colonocytes. Colonocytes were exposed in-vitro to different concentrations of DBAN (0.1-2.0 mM) for 60 min. Also, colonocytes were incubated with DBAN (1.0 mM) for different time intervals extend...

The susceptibility of low-density lipoprotein (LDL) to oxidation was studied in hypertriglyceridemic men (5 with type III and 5 with type IV) at baseline on a low-saturated-fat, low-cholesterol diet, after 6 weeks of dietary supplementation with fish oil (Promega, 12 g/d), and after 6 weeks of fish oil combined with probucol (500 mg BID). The relative content of n-3 polyunsaturated fatty acids ...

OBJECTIVES The objective of this study was to test the predictive value of an oxidative stress biomarker in 634 patients from the Prospective Randomized Evaluation of the Vascular Effects of Norvasc Trial (PREVENT). BACKGROUND Oxidative stress contributes to mechanisms of atherosclerosis and plaque instability. Biomarkers of oxidation, such as malondialdehyde (MDA), may represent independent ...

Irradiated samples had higher thiobarbituric acid reactive substances (TBARS) than nonirradiated at day 0 but the difference disappeared during storage in both packaging types. Storage increased the production of volatiles and changed the composition of volatiles only in aerobic-packaged sausage. Irradiation and the fatty acid composition had significant effects on lipid oxidation, volatile pro...

The objective was to determine if encapsulation would improve the antioxidative property of phosphate in cooked muscle foods. Encapsulation of phosphate was done to protect the phosphate from endogenous phosphatases during the raw meat manufacturing steps. An initial experiment involved incorporation of encapsulated phosphates (0.5% sodium tripolyphosphate, STP or 0.5% sodium acid pyrophosphate...

OBJECTIVES The objective of this study was to test the predictive value of an oxidative stress biomarker in 634 patients from the Prospective Randomized Evaluation of the Vascular Effects of Norvasc Trial (PREVENT). BACKGROUND Oxidative stress contributes to mechanisms of atherosclerosis and plaque instability. Biomarkers of oxidation, such as malondialdehyde (MDA), may represent independent in...

Lipopolysaccharide (LPS), called endotoxin, is a major component of Gram-negative bacteria cell wall. LPS stimulates the synthesis and release of several metabolites from mammalian phagocytes which leads to fulminant systemic inflammation (endotoxic shock). Among LPS-induced metabolites, reactive oxygen species are considered to play crucial role in the pathogenesis of endotoxic shock via oxida...

Melatonin has recently been suggested as an antioxidant that may protect neurons from oxidative stress. Acute ethanol administration produces both lipid peroxidation as an indicator of oxidative stress in the brain and impairs water-maze performance in spatial learning and memory tasks. The present study investigated the effect of melatonin against ethanol-induced oxidative stress and spatial m...