Background Little is known about treatment eligibility in Africa for the hepatitis B virus (TREAT-B) algorithm. We investigated among HBV chronically infected patients a low and high endemic region using TREAT-B Methods recruited 227 treatment-naïve HBV-infected hospital attendees from regions. assessed by testing HBeAg serostatus ALT levels. Socio-demographic data were collected with structure...

Background Glucose metabolic reprogramming (GMR) is a cardinal feature of carcinogenesis and metastasis. However, the underlying mechanisms have not been fully elucidated. The aim this study was to profile signature primary tumor circulating cells from metastatic colorectal cancer (mCRC) patients using integrated omics analysis. Methods PET-CT imaging, serum metabolomics, genomics proteomics da...

Previous studies found that some metals could affect liver function. However, the effect of strontium (Sr) exposure on function has not been evaluated. A cross-sectional study involved 1021 residents from a mining area in Hunan Province, China. This was conducted to first investigate effects Sr alone as well combined with five other heavy metals, including lead (Pb), cadmium (Cd), manganese (Mn...

the purpose of this experiment was to determine the effect of long-term low-dose administration of mercury (hg) on thyroid function in sheep. in this experiment, 10 clinically healthy, adult, male iranian sheep, aged approximately 1 year, were randomly allocated into the control (n=5) and mercury (hg-)-treated (n=5) groups. both groups were kept under identical conditions in terms of food and e...

Abstract Background The accurate and comprehensive evaluation of liver reserve function is crucial for daily follow-up medical treatment patients with disease. However, existing techniques are too complex costly universal implementation.To develop a convenient, reliable method to evaluate based on eight biochemical indicators measured from venous blood. Methods Blood test results (albumin (Alb)...

Background: COVID-19 has become a focus of healthcare practitioners worldwide after it was declared as global pandemic. Although SARS-CoV-2 is primarily affecting the respiratory system, numerous studies have documented its impact on other organ systems, including liver. This study aims to assess liver function in patients light SARS-CoV-2's extremely infectious and pathogenic character.
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Fermented papaya extracts (FPEs) are obtained by fermentation of papaya by Aspergillus oryzae and yeasts. In this study, we investigated the protective effects of FPEs on mammary gland hyperplasia induced by estrogen and progestogen. Rats were randomly divided into 6 groups, including a control group, an FPE-alone group, a model group, and three FPE treatment groups (each receiving 30, 15, or 5...

Objective: To explore the prognostic factors of hepatic encephalopathy (HE) for survival. Methods: We retrospectively reviewed the clinical data of 282 hepatic encephalopathy patients from January 2012 to May 2014 in our hospital. Data base was built using Excel and SPSS 18.0. Multivariate logistic regression statistics were used to analyze 21 possible risk factors, including gender, age, ALB, ...

OBJECTIVE To investigate the predictive effect of major adverse cardiac events (MACE) in malignant obstructive jaundice (OJ) patients using plasma brain natriuretic peptide (BNP) level and surgical Apgar scoring (SAS) system. METHODS Forty one malignant OJ patients undergoing surgical treatments were studied at a single center. Pre-and postoperative plasma BNP level, total bilirubin (TBil) an...

Aim: In this study, sub-acute toxicity of deltamethrin on hematological and biochemical blood parameters of male albino Swiss mice was evaluated. Materials and Methods: Generally, the maximum permissible residue level (MRL) of deltamethrin for food products lies between 0.01 to 0.5 mg/kg body weight. So the mice were exposed orally with two doses of pesticide i.e. 0.1 and 0.5 mg/kg body weight....