Objective: This study aimed to investigate quality of life and survival of patients with malignant bile duct obstruction after different endoscopic retrograde cholangiopancreatography (ERCP)-based treatments. Methods: A total of 41 patients with malignant bile duct obstruction were treated by ERCP with nasal biliary drainage, ERCP with endoscopic stent insertion, or ERCP combined with radiother...

The study probed the association between bilirubin and hepatitis B virus (HBV) infection and progression. A cross-sectional analysis of 28,500 middle aged and elderly Chinese participants was performed to analyze the differences of bilirubin in terms of hepatitis B surface antigen (HBsAg) positive or negative and the correlation between bilirubin and severity of hepatic fibrosis estimated by no...

GOALS To evaluate the therapeutic efficacy of rat bone marrow mesenchymal stem cells (BMSCs) induced into hepatocyte-like cells and of un-induced BMSCs in acute liver failure rats. METHODS BMSCs in highly homogenous passage 3 were cultured using the whole bone marrow adherent culture method. Hepatic-related characters were confirmed with morphology, RT-PCR analysis, glycogen staining and albu...

Objective. To use a rabbit model of parenteral nutrition-associated liver disease (PNALD) to study changes of the endoplasmic reticulum stress (ERS) marker glucose regulatory protein 94 (GRP94) and determine its role in the pathogenesis of PNALD. Methods. A rabbit PNALD model total parenteral nutrition (TPN) group was established. A corresponding control group received breast-feeding for one we...

background: some species of grass cause poisoning and hepatogenous photosensitization in animals. objectives: feeding trials were conducted in sheep and goats to evaluate the hepatotoxic effects of setaria italica (s. italica). methods: twelve indigenous male sheep and goats were used in this study. the animals were kept outdoors against prevailing climatic conditions. they were fed with s. ita...

Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) primarily manifests in neonates or infants with hepatomegaly, liver dysfunction, and hypoglycemia. This study investigated the functions of islet beta cells and their correlations with liver dysfunction in NICCD patients.We retrospectively analyzed clinical data on liver function and islet beta cell functions for 36 patients ...

To investigate the therapeutic effect of combined Xiao-Chaihu-Decoction and naturopathic medicine therapy on survival outcomes of patients' PLC. In XCHD group (n = 76), patients were treated with Xiao-Chaihu-Decoction in accordance with the addition and subtraction theory of TCM; in NM group (n = 89), patients were managed by naturopathic medicine; in combined group (n = 70), the same volume of...

Objective: To explore the effect of Multi-oil Fat Emulsion (SMOF) in perioperative parenteral nutritional support on older patients with gastric cancer. Methods: 120 patients with gastric cancer were evenly and randomly assigned to Control, Intralipid and SMOF group. Nutritional status, immune function and liver function in three groups were compared among 0 dpo (day post operation), 3 dpo and ...

We here document discovery of expression profile of myeloid derived suppressor cells (MDSCs) in chronic hepatitis B (CHB) patients and changes in the course of disease. The study population was composed of 75 outpatient HBV cases and 15 healthy control cases. Peripheral blood samples were collected for separation of mononuclear cells. Levels of MDSCs labeled with Lin-DR-CD11b+CD33+ obtained fro...

Objective: In this study the comparative hepato-protective efficacy of aqueous, ethanolic or benzene-acetone extracts of Butea monosperma (AEBM, EESC and BAEBM, respectively) were evaluated in carbon tetra chloride (CCl4) and isoniazid (INH) induced toxicity. Material & Method: For this, two parallel sets of experiments were performed. Hepatotoxicity was induced by either single dose of CCl4 or...