BACKGROUND Activation of Kupffer cell (KC) is acknowledged as a key event in the initiation and perpetuation of bile duct warm ischemia/reperfusion injury. The inhibitory effect of gadolinium chloride (GdCl(3)) on KC activation shows potential as a protective intervention in liver injury, but there is less research with regard to bile duct injury. METHODS Sixty-five male Sprague-Dawley rats (...

BACKGROUND & AIMS HBV-related acute-on-chronic liver failure (HBV-ACLF) is a severe liver disease which results in a high mortality in China. To early predict the prognosis of the patients may prevent the complications and improve the survival. This study was aimed to develop a new prognostic index to estimate the survival related to HBV-ACLF. METHODS Consecutive patients with HBV-ACLF were i...

The clinical efficacy and safety of different combinations of non-bio artificial liver in the treatment of acute liver failure was examined. A total of 61 cases were selected under blood purification treatment from the patients with severe acute liver failure admitted to the severe disease department of the hospital from December, 2010 to December, 2015. Three types of artificial liver combinat...

BACKGROUND Acute liver failure (ALF) caused by viral and non-viral hepatitis is often accompanied with severe metabolic disorders, the accumulation of toxic substances and continuous release and accumulation of a large number of endogenous toxins and inflammatory mediators. The present study aimed to investigate the effects of various combined non-biological artificial liver treatments for pati...

Objective: To study the value of ALT / ALP ratio (R value) for the differential diagnosis of hepatocellular jaundice and cholestatic jaundice and compare the diagnostic sensitivity of R values and the traditional D / T (DBIL / TBIL) values. Method: We randomly collected 336 cases patients with confirmed diagnosis of dominant jaundice from January 2004 to December 2006 in our hospital and record...

Objectives: Increased CA199 serum level is a key prognostic factor of carcinoma of the ampulla of vater (CAV) after surgery; the prognostic value of other serum markers like CA242, CEA, LDH, NLR and TBIL has yet not been defined. Methods: We pooled one week pre-treatment data on serum factors from 147 CAV patients in Tumor Hospital of Chinese Academy of Medical Sciences from January 1998 to Dec...

Objective(s):This study aimed to establish a novel non-binding, reversible rat model of acute cholangitis of the severe type (ACST). Materials and Methods:Twenty-six rats were randomly divided into the sham-operated group (n=13) and the ACST group (n=13). All rats were intubated with a modified catheter through the external jugular vein. The ACST model was established by ligation of the distal ...

BACKGROUND The effectiveness of nucleoside analogue (NA) treatment in patients with chronic hepatitis B (CHB) -associated liver failure is still controversial. Severe lactic acidosis has been reported during entecavir (ETV) treatment in patients with impaired liver function. AIM To investigate the rescuing efficacy and safety of ETV in patients with CHB-associated liver failure. MATERIAL AN...

The aim of the present study was to investigate the effect of endogenous carbon monoxide (CO) on the hydrogen sulfide/cystathionine-γ-lyase (H2S/CSE) pathway in cirrhotic rat livers. The rats were allocated at random into four groups: Sham, cirrhosis, cobalt protoporphyrin (CoPP) and zinc protoporphyrin IX (ZnPP). The expression of hepatic CSE mRNA was evaluated using a quantitative polymerase ...

BACKGROUND/AIMS Primary biliary cirrhosis (PBC), an autoimmune disease of the liver, is marked by slow progressive destruction of bile ducts. These patients with PBC often undergo orthotopic liver transplantation (OLT). Ischemic bile duct lesion (IBDL) is a major source of morbidity and even mortality after OLT. Cirrhosis of the liver has a higher tolerance to ischemia than a normal liver, but ...