A successful HIV vaccine in addition to induction of antibody responses should elicit effective T cell responses. Here we described possible strategies for rational design of T-cell vaccine capable to induce high levels of both CD4+ and CD8+ T- cell responses. We developed artificial HIV-1 polyepitope T-cell immunogens based on the conserved natural CD8+ and CD4+ T cell epitopes from different ...

BACKGROUND Interhemispheric inhibition might be a beneficial cortico-cortical interaction, but also might be maladaptive in people with neurological disorders. One recently revisited technique that has been shown to be effective in improving motor function in people with stroke using interhemispheric modulation is transcranial direct current stimulation (tDCS). OBJECTIVE The aim of this study...

The purpose of this study was to examine the biopsychological personality profiles of traditional Korean Sasang typology based on the Temperament and Character Inventory (TCI) in a Korean adult clinical sample. A total of 97 adults completed the Korean version of the TCI. The participants were classified as one of three traditional Korean Sasang types (31 So-Yang, 41 Tae-Eum, 25 So-Eum) by thre...

• Objective: To compare the frequency of injury to clients and staff with use of 2 restraint systems. • Design: Retrospective database review. • Setting and participants: Youth admitted under both voluntary and involuntary commitments to residential behavioral and mental health programs in Pennsylvania and New York and staff from these institutions. • Methods: Restraint events that occurred dur...

Trade credit insurance (TCI) is a risk management tool commonly used by suppliers to guarantee against payment default buyers. TCI contracts can be either cancelable (the insurer has the discretion cancel this during insured period) or noncancelable terms cannot renegotiated within period). This paper identifies two roles of TCI: (cash flow) smoothing role (smoothing supplier’s cash flows) and ...

Abstract Background Transcatheter edge-to-edge repair (TEER) with the MitraClip system is an alternative procedure for treatment of severe mitral regurgitation (MR) in high-risk patients who are not suitable conventional surgery and usually performed under general anaesthesia (GA). GA may be associated potential haemodynamic complications. A new approach deep sedation (DS) spontaneous breathing...

The Travel and Tourism Competitiveness Index (T&TCI) seems to be the most used measure of a destination’s competitiveness, even though methodology underlying its calculation is characterized by numerous shortcomings. viability T&TCI as reliable country’s competitive capability should stem from ability explain and/or predict performance-related consequences tourism activity within destin...

Objective: The aim of this study was to examine the association between circadian types, temperament, and character. Methods: We analyze the data obtained from a total of 2910 students who undertook the Temperament and Character Inventory (TCI) and the Composite Scale of MorningnessEveningness (CSM). According to the CSM score, the circadian types were classified as the morning type (MT), neith...

BACKGROUND We previously suggested that abnormal sleep behaviors, i.e., as found in parasomnias, may often be the expression of increased activity of the reward system during sleep. Because nightmares and sleepwalking predominate during REM and NREM sleep respectively, we tested here whether exploratory excitability, a waking personality trait reflecting high activity within the mesolimbic dopa...