Acandidate vaccine CombiHIVvac is developed; presently the clinical phase I trial has been completed successfully. CombiHIVvac combines the conserved polyepitope immunogens approaches in a novel self-adjuvanted microparticle concept. The artificial TBI (T cell and B cell immunogen) polypeptide used in the vaccine comprises epitopes from Env and Gag. The polypeptide is conjugated to dextran and ...

OBJECTIVE Advances in dimensional assessment of children in healthy and clinical populations has renewed interest in the study of temperament. Cloninger's Temperament and Character Inventory (TCI) has shown high reliability and internal consistency. Adult and adolescent versions have been translated into a number of languages and validated in cross-cultural studies worldwide. To date only one p...

Climate has a strong influence on the tourism and recreation sector and in some regions represents the natural resource on which the tourism industry is predicated. There has been little consideration of how climate change might affect the tourism climate resource or how such changes could alter the competitive relationships between tourism destinations. This study used a modified version of Mi...

Objective: The aim of this study was to examine the association between circadian types, temperament, and character. Methods: We analyze the data obtained from a total of 2910 students who undertook the Temperament and Character Inventory (TCI) and the Composite Scale of MorningnessEveningness (CSM). According to the CSM score, the circadian types were classified as the morning type (MT), neith...

BACKGROUND Patients have anxiety and fear of complications due to general anesthesia. Through new instruments and local anesthetic drugs, a variety of anesthetic methods have been introduced. These methods keep hospital costs down and save time for patients. In particular, the target-controlled infusion (TCI) system maintains a relatively accurate level of plasma concentration, so the depth of ...

OBJECTIVE The Psychopathy Checklist Revised (PCL-R) and Temperament and Character Inventory (TCI) have been used extensively in research of personality disorders; however, no previous study has investigated the relation between psychopathy factors and temperament and character traits in patients with antisocial personality disorder (ASPD). Our aim was to fill this gap in the literature. METHO...

UV radiation of the skin impairs immune responses to haptens and to tumor Ags. Transcutaneous immunization (TCI) is an effective method of inducing immune responses to protein and peptide Ag. We explore the effect of UV irradiation on TCI. The generation of Ag-specific CTL to OVA protein, but not class I MHC-restricted OVA peptide, is inhibited by TCI through UV-irradiated skin. Consequently, t...

Background: Post-induction hypotension frequently occurs and can lead to adverse outcomes. As target-controlled infusion (TCI) obviates the need calculate rate manually helps safer dosing with prompt titration of drug using complex pharmacokinetic models, use TCI may provide a better hemodynamic profile during anesthesia induction. This study aimed compare versus manual induction determine risk...

BACKGROUND Lidocaine is a useful intravenous and topical adjunct to facilitate tracheal intubation. We evaluated the effect of tracheal lidocaine on tracheal intubating conditions without neuromuscular blocking agent and hemodynamics during anesthesia induction with propofol and remifentanil target-controlled infusion (TCI). METHODS Fifty patients, aged 18-60 years, scheduled for closed reduc...