The prognosis of T-cell lymphoma (TCL) has been shown to be associated with the clinical characteristics of patients. However, there is little knowledge of whether genetic variations also affect the prognosis of TCL. This study investigated the associations between single nucleotide polymorphisms(SNPs) in tumor necrosis factor receptor superfamily(TNFRSF) genes and the survival of patients with...

The Cactvs Chemoinformatics Toolkit is probably the most powerful general-purpose chemical information processing toolkit on the market. Since its inception about twenty years ago, its main language for rapid script development has been Tcl – at that time a language at the forefront of lazily-typed rapid prototyping and interface programming language design. While Tcl is still actively maintain...

PURPOSE Aurora A kinase (AAK) is expressed exclusively during mitosis, and plays a critical role in centrosome duplication and spindle formation. Alisertib is a highly selective AAK inhibitor that has demonstrated marked clinical activity of alisertib across a spectrum of lymphomas, though particularly in patients with T-cell lymphoma (TCL). We sought to compare and contrast the activity of ali...

BACKGROUND Diagnosis of bundle-branch reentry ventricular tachycardia (BBR-VT) by the standard approach is challenging, and this may lead to nonrecognition of this tachycardia mechanism. Because the postpacing interval (PPI) after entrainment has been correlated with the distance from the pacing site to the reentrant circuit, BBR-VT entrainment by pacing from the right ventricular apex (RVA) sh...

T cell lines (TCLs) specific for Schistosoma japonicum egg antigen were established from a patient with chronic schistosomiasis japonica to investigate the regulatory mechanism of S.japonicum egg antigen-driven T cell responses in man. All five TCLs tested were CD2+, CD4+, CD8-, and were strongly proliferative only to S. japonicum egg antigen in the absence of exogenous IL-2. All but one TCL pr...

BACKGROUND The purpose of this work was to collect construct and criterion-related evidence of validity for a reading comprehension test (TCL - Teste de Compreensão da Leitura) with three vertically scaled forms, designed to assess students from second, third and fourth grade. METHOD Two studies were conducted. In the first (n = 1,229), a confirmatory factor analysis was performed to analyse ...

This paper describes the motivations and strategies behind our group’s efforts to integrate the Tcl and Java programming languages. From the Java perspective, we wish to create a powerful scripting solution for Java applications and operating environments. From the Tcl perspective, we want to allow for cross-platform Tcl extensions and leverage the useful features and user community Java has to...

In this paper, we present a time-contrastive learning (TCL) based unsupervised bottleneck (BN) feature extraction method for speech signals with an application to speaker verification. The method exploits the temporal structure of a speech signal and more specifically, it trains deep neural networks (DNNs) to discriminate temporal events obtained by uniformly segmenting the signal without using...

Application-level scripting is a powerful method for structuring software. This paper introduces TkDVI, a TEX DVI previewer based on the Tcl/Tk scripting language and graphics toolkit. After a brief introduction to Tcl/Tk, we present the design and major components of the previewer, pointing out the specific advantages gained by using Tcl/Tk. A number of extensions and future projects is also d...

A set of Tcl/Tk Version 8 scripts supports a telethon that raises money for needy families. This paper describes the system and how it was constructed. Because the system uses nearly every major feature of the Tcl and Tk system, including the Tcl web server, this paper serves as an example that emphasizes the power of universal scripting in both the development and deployment of a distributed s...