HIT (Harmonisierung und Integration des MAN-TDB-Datenbestandes) ist ein Migrationsprojekt, welches abteilungsspezifische Einzelplatzlösungen in ein webbasiertes System konvertiert. Im Vergleich zu klassischen Migrationsprojekten beinhaltet HIT einen signifikanten Anteil neuentwickelter Komponenten sowie Schnittstellen zu externen Prozessen. Im Rahmen des Projektes wurden spezielle Migrationstoo...

Objectives Heparin-binding hemagglutinin (HBHA), a mycobacterial cell surface protein, mediates adhesion to nonphagocytic cells and the dissemination of Mycobacterium tuberculosis (M. tuberculosis) from the site of primary infection. Superior expression systems are required to obtain abundant M. tuberculosis proteins for the purpose of diagnosing M. tuberculosis infection or for the immunizatio...

We compare the cellular efficacy of two selective and cell permeable inhibitors of the antiapoptotic kinase CK2. One inhibitor, CX-4945, is already in clinical trials as antitumor drug, while the other, TDB, has been recently successfully employed to demonstrate the implication of CK2 in cellular (dis)regulation. We found that, upon treatment of cancer cells with these compounds, the extent of ...

background: diabetes is a major public health problem. the development of new therapies that are able to improve glycemia management and even to cure diabetes is of great interest. in this study, protective effects of sodium tungstate against stz-induced beta-cell damages were investigated. methods: sixty rats were divided into six groups: control, diabetic, sodium tungstate treated diabetic ra...

Prolonged ischemia can result in apoptotic death of vascular endothelial cells and lead to ischemic vascular diseases including vascular dementia, arteriosclerosis and brain oedema. Finding protective strategies to prevent this is therefore an urgent mission. Recent studies have shown that dysregulation of microRNAs (miRNAs) can lead to imbalance of Bcl-2 family proteins and mitochondrial dysfu...

Fifty three patients with endoscopically proven duodenal ulceration have cooperated in a clinical trial to compare the ulcer healing effect of tripotassium dicitrato bismuthate (TDB) at standard dosage administered either twice or four times daily. No statistically significant difference has been found to exist between ulcer healing in the two groups at 4 weeks (72% and 67%, P = 0.944) or at 8 ...

Le CRM analytique dans les entreprises De plus en plus d'utilisateurs potentiels ■ Utilisateurs métier ET PAS experts (BI, data mining) Les entreprises veulent produire de plus en plus Typiquement par an Des 1 000s de Tableaux de Bord, Des 100s de modèles Ce qui exige ■ Plus de gens doivent pouvoir produire ces TdB / modèles ■ Or il y a Beaucoup d'utilisateurs métier (plusieurs 1 000 000 s) Peu...

OBJECTIVES The aim of the present study was to verify whether the implementation of an electronic health record (EHR) in our thoracic surgery unit allows creation of a high-quality clinical database saving time and costs. METHODS Before August 2011, multiple individuals compiled the on-paper documents/records and a single data manager inputted selected data into the database (traditional data...

In this paper, we report on the annotation procedures we developed for annotating the Turkish Discourse Bank (TDB), an effort that extends the Penn Discourse Tree Bank (PDTB) annotation style by using it for annotating Turkish discourse. After a brief introduction to the TDB, we describe the annotation cycle and the annotation scheme we developed, defining which parts of the scheme are an exten...

Stochastic reduced-order modeling based on time-dependent bases (TDBs) has proven successful for extracting and exploiting low-dimensional manifold from stochastic partial differential equations (SPDEs). The nominal computational cost of solving a rank-$r$ model (ROM) basis, a.k.a. TDB-ROM, is roughly equal to that the full-order $r$ random samples. As now, this performance can only be achieved...