PURPOSE Although elevated blood pressure (BP) predicts future cardiovascular events, recommended BP targets often is not reached in the general community. In a clinical real-life setting we evaluated BP impact and tolerability of the angiotensin-II receptor blocker telmisartan in patients with essential hypertension. PATIENTS AND METHODS Patients in this observational study not at target BP s...

The aim of this study was to clarify the effects of renin-angiotensin system (RAS) blockade by captopril, an angiotensin converting enzyme inhibitor, and telmisartan, an angiotensin II type 1 receptor antagonist, on matrix metalloproteinase (MMP)-2 and MMP-9 expressions and development of left ventricular (LV) fibrosis induced by isoprenaline in rats. Rats were treated with subcutaneous injecti...

Objective This study compared the pharmacokinetic (PK) and safety profiles of a fixed-dose combination (FDC) formulation of telmisartan and S-amlodipine with those of concomitant administration of the two drugs. Materials and methods This was an open-label, randomized, crossover study in healthy male Koreans. All subjects were administered an FDC tablet containing 40 mg telmisartan and 5 mg S...

BACKGROUND Diabetic cardiovascular disease is associated with decreased adiponectin and increased oxidative stress. This study investigated the effect of telmisartan on the expression of adiponectin receptor 2 (adipoR2) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits in the heart and the expression of adiponectin receptor 1 (adipoR1) in aorta in type 2 diabetic rats. ...

Background: Epidemiological studies and clinical trials have shown that meticulous control of blood pressure is required in patients with hypertension to ensure decreased cardiovascular morbidity and mortality. Objective: To compare the effect of Metoprolol and Telmisartan on blood pressure reduction and heart rate in patients of Stage I Hypertension. Material and Methods: This was a prospectiv...

Fixed dose complex dual-layer tablets of telmisartan and rosuvastatin calcium have been used for the treatment hypertension hyperlipidemia. However, current United States Pharmacopoeia analysis method is limited by need twice time cost owing to each active pharmaceutical ingredient present separately. Due critical limitations in establishing simultaneous methods both ingredients, there an urgen...

AIMS Left ventricular (LV) torsion may be an important component of normal LV systolic function. However, its mechanics remain unresolved. Two-dimensional (2-D) strain imaging is increasingly used to quantify LV torsion in the clinical setting. Telmisartan has cardioreparative effects, including attenuation of subendocardial myocardial fibrosis and improvement of LV remodelling. To clarify the ...

Telmisartan is an effective antihypertensive agent. In ONTARGET study, it was non-inferior to ramipril in preventing vascular events in high risk patients, and was better tolerated. In ROADMAP study, though olmesartan delayed the onset of microalbuminuria in patients with type 2 diabetes and normoalbuminuria, a greater number had fatal cardiovascular (CV) events. NAVIGATOR study demonstrated th...

Background: Long-lasting hyperglycemia in type 1 diabetic patients induces permanent alterations of endothelial function, by increased oxidative stress, even when glycemia is normalized. Methods and Results: In this study 36 type 1 diabetic patients and 12 controls were enrolled. The diabetic patients were divided in three groups. The first group was treated for 24h with insulin, achieving a ne...

AIMS We tested the hypothesis that renin-angiotensin system inhibition could reverse left ventricular diastolic dysfunction in patients with type 2 diabetes. METHODS AND RESULTS Forty asymptomatic patients with type 2 diabetes were recruited in this double-blind cross-over trial. Left ventricular diastolic function was assessed at baseline with Doppler echocardiography; ratios of early to lat...