Abstract: Cilazapril is a drug commonly used in management of heart failure in pediatric population. On pharmaceutical market it is available only in inconvenient for pediatric use tablet dosage forms. Until now, no oral liquid formulation containing cilazapril has been evaluated. Therefore, the aim of this study was to prepare easy to made and palatable 1 mg/mL oral liquid formulation with cil...

Comparison of the conformational stability of an O(6)-methylguanine-DNA methyltransferase (MGMT) from the hyperthermophilic archaeon Thermococcus kodakaraensis strain KOD1 (Tk-MGMT), and its mesophilic counterpart C-terminal Ada protein from Escherichia coli (Ec-AdaC) was performed in order to obtain information about the relationship between thermal stability and other factors, such as thermod...

We examine the variability of the ocean’s thermohaline circulation in a Oceanic General Circulation Model (OGCM) coupled to a two dimensional atmospheric Energy Balance Model (EBM). The EBM calculates air temperatures by balancing heat fluxes, including that from the ocean surface; air temperature and ocean circulation evolve together without imposed temperature restrictions except specificatio...

This paper draws a comparison between social stability and chemical reaction process, and brings forward the concept of “social temperature” and “activation energy of social agent”. It is considered that social temperature turns out to be the macro symptom of social average energy, and its unceasing upclimbing roots in the energy accumulation of “inferiorization” process of social system; that ...

The neutron density is one of the most important dynamical parameters in a reactor. It is directly related to the control and stability of the reactor power. Any change in applied reactivity and some of dynamical parameters in the reactor causes a change in the neutron density. Lyapunov exponent method is a powerful tool for investigating the range of stability and the transient behavior of the...

in previous researches, mechanical behavior of a microgripper with homogenous and the same material has been studied. in this paper considering the desired characteristics of fgms, as a good thermal and wear resistance, the mechanical behavior of fgm microgripper under dc voltage and temperature variations is investigated. it is assumed that the two microbeams of the fgm microgripper are mounte...

aacel9a [β-1,4-endoglucanase, (e.c:3.2.1.4)], was immobilized onto glutaraldehyde activated chitosan macrosphere by covalent attachment. the properties of the immobilized aacel9a were investigated by determining the optimum ph and optimum temperature for activity, thermal stability, and kinetic parameters. the immobilization process shifted the enzyme’s optimum temperature from 65 °c for the fr...

We obtain estimates for critical nematic liquid crystal (LC) temperatures under the action of a slowly varying temperature-dependent control variable. We show that biaxiality has a negligible effect within our model and that these delay estimates are well described by a purely uniaxial model. The static theory predicts two critical temperatures: the supercooling temperature below which the isot...

Stable, nanometer-thick films are observed to form at the {1120} facets of Bi(2)O(3)-doped ZnO in several bulk-phase stability fields. Electron microscopy shows these surficial films to exhibit some degree of partial order in quenched samples. The equilibrium film thickness, corresponding to the Gibbs excess solute, decreases monotonically with decreasing temperature until vanishing at a dewett...