CONTEXT - The number of targeted next-generation sequencing (NGS) panels for genetic diseases offered by clinical laboratories is rapidly increasing. Before an NGS-based test is implemented in a clinical laboratory, appropriate validation studies are needed to determine the performance characteristics of the test. OBJECTIVE - To provide examples of assay design and validation of targeted NGS ...

This paper is based on the insight that intelligent system validation is a complex social process involving issues ranging from mathematics and software engineering to cognitive psychology and social sciences. To cope with the intrinsic complexity of the problem, there is developed a so-called \Tur-ing Test Methodology" for intelligent system validation. This is substantially distinguished from...

Concern about Internet addiction, fuelled by the rapid increase in its usage across the globe, has spread to many parts of the world, including the Arab world. Concurrently, there has been a relentless quest for a valid tool for measuring Internet addiction. Thus far, two popular tools have been translated to Arabic: the Compulsive Internet Use Scale and the Internet addiction test (IAT). While...

The main goal of the present study is to investigate the psychometric properties of a French version of the Internet Addiction Test (IAT) and to assess its relationship with both time spent on Internet and online gaming. The French version of the Young's Internet Addiction Test (IAT) was administered to a sample of 246 adults. Exploratory and confirmatory analyses were carried out. We discovere...

BACKGROUND Script Concordance Test (SCT) is a new assessment tool that reliably assesses clinical reasoning skills. Previous descriptions of developing SCT-question banks were merely subjective. This study addresses two gaps in the literature: 1) conducting the first phase of a multistep validation process of SCT in Plastic Surgery, and 2) providing an objective methodology to construct a quest...

Increasing design complexity, shrinking time to market, and high cost of fixing a bug in a released product [11] make functional validation of microprocessors a key ingredient in the product development cycle. Simulation is widely used to validate large systems like microprocessors. In simulation based validation, a test is executed in a golden reference model as well as in the design under tes...

This paper considers a statistical model for the detection mechanism of qualitative microbiological test methods with a parameter for the detection proportion (the probability to detect a single organism) and a parameter for the false positive rate. It is demonstrated that the detection proportion and the bacterial density cannot be estimated separately, not even in a multiple dilution experime...

In March of 2013, the American College of Medical Genetics and Genomics (ACMG) issued recommendations for the reporting of incidental findings produced by clinical exome and genome sequencing (1, 2 ). This guideline on incidental findings has been controversial, because the recommendations are a departure from previous ethical concepts of patient autonomy and the reporting of adult-onset diseas...

BACKGROUND Generally, QSAR modelling requires both model selection and validation since there is no a priori knowledge about the optimal QSAR model. Prediction errors (PE) are frequently used to select and to assess the models under study. Reliable estimation of prediction errors is challenging - especially under model uncertainty - and requires independent test objects. These test objects must...