In the article data about content of estradiol, progesterone and testosterone were determined in patients with epilepsy period between seizures. These results show changes functional state hypophysis-gonad system epileptics. It was shown that women decreasing concentration noted increasing level estrogenes too, at background nomal testosterone. expressed 2 phase menstrual cycle. men attacks gen...

The number of requests for testosterone testing in adult males has been increasing in recent years. In this review, the biochemistry and physiology of testosterone in males relevant to the chemical pathologist or clinical biochemist is outlined. The methodology for total testosterone and various laboratory tests associated with the assessment of testosterone status including free testosterone, ...

one, a significant portion of CBGbound testosterone. We kindly invite Drs. Pardridge and Demers toprovide evidence to the contrary. Our observations merely indicate that there may be a moderate increase of testosterone secretion in consequence of corticotropin stimulation of the adrenals, which is reflected by total, free, and salivary testosterone concentrations, and also (probably) by the alb...

Testosterone affects human social behavior in various ways. While testosterone effects are generally associated with muscular strength and aggressiveness, human studies also point towards enhanced status-seeking motives after testosterone administration. The current study tested the causal influence of exogenous testosterone on male behavior during a competitive provocation paradigm. In this do...

PURPOSE Pubertal dynamics plays an important role in physical and psychological development of children and adolescents. We aim to provide reference ranges of plasma testosterone in a large longitudinal sample. Furthermore, we describe a measure of testosterone trajectories during adolescence that can be used in future investigations of development. METHODS We carried out longitudinal measure...

Background: Spinal cord injury (SCI) is a traumatic or nontraumatic injury that can leads to loss of functions such as feeling or mobility along with permanent and debilitating influences on the patient’s quality of life. Patients with SCI have weakened sexual function and a distinctive sperm profile described by normal to high sperm concentrations and unusually low sperm mobility. The reason o...

BACKGROUND Saliva reflects the plasma free fraction of testosterone which is biologically active, and available for uptake by tissues. Testosterone concentration in saliva, though differing slightly from the concentration of unbound testosterone in serum, is in good correlation with the latter, indicating that salivary testosterone provides a reliable method for determination of serum free test...

OBJECTIVE To determine the pharmacokinetics of testosterone following its administration using transdermal gel or buccal lozenges. DESIGN Pilot study. SETTING University-based hospital. PATIENT(S) Ten bilaterally oophorectomized women. INTERVENTION(S) Daily micronized testosterone gel (1 mg) and testosterone propionate lozenge (1 mg). MAIN OUTCOME MEASURE(S) Total testosterone, andros...

BACKGROUND Fetal exposure to testosterone has been implicated in programming childhood behaviour, but little is known about the determinants of fetal testosterone concentrations. AIMS To investigate the relation between fetal testosterone and maternal and fetal cortisol. METHODS Clinically indicated blood samples taken from 44 human fetuses (mean gestational age 27 weeks, range 15-38), toge...

Women are generally more risk averse than men. We investigated whether between- and within-gender variation in financial risk aversion was accounted for by variation in salivary concentrations of testosterone and in markers of prenatal testosterone exposure in a sample of >500 MBA students. Higher levels of circulating testosterone were associated with lower risk aversion among women, but not a...