OBJECTIVE To provide the first multinational survey of temporal trends in testosterone prescribing, given that anecdotal evidence indicates that it is increasing in some countries, including Australia. DESIGN Sales data for all testosterone products were obtained for 41 countries for each year from 2000 to 2011. For each testosterone product type (injectable, implantable, oral, transdermal), ...

conclusions it seems that testosterone in low dose, i.e. physiologic dose, protects kidneys against cp-induced nephrotoxicity; however, special care is needed in cp therapy of patients with high levels of ts. results cp increased the serum levels of blood urea nitrogen (bun), creatinine (cr), and malondialdehyde (smda) as well as kidney weight (kw), bodyweight (bw) loss, and kidney tissue damag...

background: acrylamide (aa) is an important industrial chemical primarily. aa is also found in carbohydrate-rich foods that are prepared at high temperatures, such as french fries and potato chips. it is demonstrated that aa is a carcinogen and reproductive toxin and has ability to induce sperm damage. objective: the aim of this study was to observe the effects of aa on sperm parameters and eva...

purpose the aim of this study was to compare the levels of serum immunoglobulin (iga, igm, igg), testosterone and cortisol in semi-endurance elite runners during general preparation and competition phase of training. methods thirteen semi-endurance elite male runners with an average age of 18.92±1.7 years volunteered to take part in this study. the runners participated in the selected training ...

background: toxoplasma gondii is an intracellular protozoan parasite that infects human and animals. toxoplasma parasites are isolated from different parts of ani-mals even from semen but there are little information about the effect of toxo-plasmosis on fertility in animals and humans. in present study, the effect of chronic toxoplasmosis on serum levels of testosterone in men was studied. met...

The medial amygdala plays a key role in regulating adult social behavior and undergoes structural changes during puberty that may be driven by gonadal hormone secretion during this developmental period. The current study sought to investigate potential organizational effects of testosterone during puberty, activational effects of testosterone in adulthood, and any interactions on regional volum...

Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n = 871) and two de novo r...

A young female with prolonged intermenstrual bleeding was found to have raised total plasma testosterone of 25.8 nmol/l (NR<2.9 nmol/l) using the Roche Elecsys Testosterone I immunoassay without clinical features of virulisation. Few months ago investigations for lethargy and low libido had shown normal total testosterone of 0.8 nmol/l. Further history revealed that she was using maca extract t...

Transdermal testosterone gels were first introduced in the US in 2000. Since then, they have emerged as a favorable mode of testosterone substitution. Serum testosterone levels reach a steady-state in the first 24 hours of application and remain in the normal range for the duration of the application. This pharmacokinetic profile is comparable to that of testosterone patch but superior to injec...

Enzyme immunoassays (EIAs) are widely used to measure salivary testosterone. However, little is known about how accurately different EIAs assess testosterone, partially because estimates across various EIAs differ considerably. We compared testosterone concentrations across EIAs of three commonly used manufacturers (DRG International, Salimetrics, and IBL International) to liquid chromatography...