background: in the visceral leishmaniasis (vl), parasites reside in reticuluendothelial system, mainly in macrophages. endothelial selectin (e-selectin) might play an important role in leukocyte-endothelium interactions and inflammatory cell recruitment. the aim of this study was determining e-selectin level and its polymorphism in three groups, patients, seroposi­tive and healthy individuals. ...

PURPOSE Approximately 95% of patients who are diagnosed with Leber's hereditary optic neuropathy (LHON) have one of three mitochondrial point mutations responsible for the disease, G3460A, G11778A, and T14484C. The purpose of this study was to develop a novel multiplex real-time amplification-refractory mutation system (ARMS) PCR combined with high-resolution melt curves to identify the individ...

BACKGROUND We aimed to evaluate the feasibility of using the allele burden of Janus kinase 2 (JAK2) V617F as a criterion for discriminating 3 subtypes of Philadelphia chromosome-negative myeloproliferative neoplasm (Ph(-)MPN): polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). METHODS We collected 70 peripheral blood (PB) and 81 bone marrow (BM) samples f...

background: spontaneous abortion is considered as the most complex problem during pregnancy. thrombophilia is resumed as a cause of recurrent pregnancy loss (rpl). glycoprotein iiia (gpiiia) gene is involved in thrombosis and abortion. angiotensin converting enzyme (ace) converts angiotensin i to angiotensin ii and is involved in thrombosis. the most common polymorphism in this gene is the inse...

abstract background: rhabdomyosarcoma is the most common soft tissue sarcoma among children which has two major subtypes: embryonal rhabdomyosarcoma (erms) and alveolar rhabdomyosarcoma (arms). distinction between these subtypes is mandatory to choose proper treatment and to determine prognosis. histopathologic study is the main method, but nowadays molecular studies like pcr are also used. the...

introduction: gestational diabetes mellitus (gdm) is defined as abnormal glucose tolerance that is first identified or diagnosedduring pregnancy.deiodinase d2 is essential for the local production of t3 through deiodination of triiodothyroxine (t4). several polymorphisms in d2 have been described. the single-nucleotide polymorphism (snp) in d2 thr92ala is associated with decreased enzyme activi...