background: multidrug resistant enterobacteriaceae which was confined to the hospital environments is now emerging in the domestic food related environments as well. the main objective of the present study was to investigate the prevalence of antibiotic resistant enterobacteriaceae in the domestic food related environments.  methods: resistance to ampicillin, chloramphenicol, ciprofloxacin, gen...

OBJECTIVES The aim of this study was to characterize the efflux pump Tap from Mycobacterium fortuitum, to test its sensitivity to well known efflux inhibitors, to study the interaction between tetracycline and these compounds and to test the ability of these compounds to overcome efflux pump-mediated tetracycline resistance. For all these studies, we produced Tap protein in Mycobacterium smegma...

Calves were fed Escbericbia coli of bovine origin containing an R factor with resistance determinants found rarely in human and bovine populations. Some of these calves received tetracycline. Fecal samples from human subjects in daily contact with the calves were analyzed for the R factor, the bovine E. coli, and changes in the levels of tetracycline resistant coliforms. Crossover from the calv...

We tested the in-vitro activity of amoxycillin, amoxycillin/clavulanic acid, cefotaxime, gentamicin, trimethoprim-sulphamethoxazole, tetracycline, norfloxacin, ciprofloxacin, vancomycin, teicoplanin, clindamycin and five psychiatric drugs (chlorpromazine, sertraline, fluoxetine, paroxetine and risperidone) against 32 strains of Corynebacterium urealyticum. Resistance rates exceeded 90% for all ...

The studies reported here demonstrate that increased resistance of Neisseria gonorrhoeae to penicillin, tetracycline, and chloramphenicol results from the combined effect of two resistance loci. As shown by experiments with deoxyribonucleic acid from transformants carrying only a single resistance locus, transformants with an incresed level of resistance to penicillin result from the combinatio...

The aim of this study was to determine the antibiotic resistance E. rhusiopathiae when isolated from clinical outbreaks erysipelas in geese antimicrobials commonly used poultry production. All isolates were susceptible amoxicillin alone or with clavulanic acid, MIC values ranging 0.016 0.125 μg/mL. Ninety-six percent fully sensitive penicillin G (MIC 0.125–0.5 μg/mL). moderately erythromycin Mo...

Antibiotic resistance in human bacterial pathogens and commensals is threatening our ability to treat infections and conduct common medical procedures. As novel antibiotics are discovered and marketed it is important that we understand how resistance to them may arise and know what environments may act as reservoirs for such resistance genes. In this study a tetracycline and tigecycline resista...

INTRODUCTION One of two main mechanisms of resistance in tetracycline-resistant Neisseria gonorrhoeae (TRNG) is associated with the presence of TetM protein responsible for actively blocking of the tetracycline target site in the 30S ribosomal subunit. This mechanism is encoded by conjugative plasmids. The second mechanism is chromosomal in nature and due to mutations in specific genes. AIM T...

Background Gonorrhoea is the third most common sexually transmitted infection (after syphilis and non-gonococcal urethritis) seen in patients attending the Genitourinary Medicine (GUM) Clinic in Hospital Kuala Lumpur (HKL). Its association with poor reproductive health outcomes and the increasing prevalence of antimicrobial resistance has made it a major public health concern. Objective To dete...

BACKGROUND Streptococcus agalactiae or Group B Streptococci (GBS) is an important bacterial pathogen that causes a wide range of infections including neonatal sepsis, meningitis, pneumonia and soft tissue or urinary tract infections. MATERIAL AND METHODS One hundred and fifteen isolates of Streptococcus agalactiae collected from urine specimens of patients attending a hospital in Tehran. All ...